The many faces of brucellosis: diagnostic and management approach.

IF 3.6 3区 医学 Q2 INFECTIOUS DISEASES Current Opinion in Infectious Diseases Pub Date : 2024-12-01 Epub Date: 2024-07-29 DOI:10.1097/QCO.0000000000001045
L'Emir Wassim El Ayoubi, Caren Challita, Souha S Kanj
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Abstract

Purpose of review: This review aims to highlight the multifaceted nature of brucellosis, emphasizing the latest advancements in its diagnosis and management. Given the global prevalence and potential complications of brucellosis, understanding recent advancements in diagnostic techniques and treatment strategies is crucial for clinicians.

Recent findings: Recent literature reveals significant progress in diagnostic methods, including the application of fluorescence polarization immunoassay and time-resolved fluorescence resonance energy transfer technologies as well as the invention of artificial Brucella antigens, which offer enhanced sensitivity and specificity. Advances in molecular diagnostics and serological tests have improved early detection rates, however their interpretation remains challenging. Evolving treatment regimens such as the use of hydroxychloroquine as part of triple therapy and the use of nano-delivery systems in therapies have shown promise, in hopes of reducing relapse rates and managing chronic cases.

Summary: The findings underscore the necessity for clinicians to adopt a comprehensive approach to diagnosing and managing brucellosis. Integrating advanced diagnostic tools with tailored therapeutic strategies can significantly improve patient outcomes. Future research should focus on optimizing these diagnostic techniques and exploring novel therapeutic agents.

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布鲁氏菌病的多面性:诊断和管理方法。
综述的目的:本综述旨在突出布鲁氏菌病的多面性,强调其诊断和管理方面的最新进展。鉴于布鲁氏菌病的全球流行性和潜在并发症,了解诊断技术和治疗策略的最新进展对临床医生至关重要:最近的文献显示,诊断方法取得了重大进展,包括荧光偏振免疫测定和时间分辨荧光共振能量转移技术的应用,以及人工布鲁氏菌抗原的发明,从而提高了灵敏度和特异性。分子诊断和血清学检测技术的进步提高了早期检测率,但对它们的解释仍然具有挑战性。不断改进的治疗方案,如使用羟氯喹作为三联疗法的一部分,以及在疗法中使用纳米给药系统,都显示出了希望降低复发率和控制慢性病例的前景。将先进的诊断工具与量身定制的治疗策略相结合,可显著改善患者的治疗效果。未来的研究应侧重于优化这些诊断技术和探索新型治疗药物。
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来源期刊
CiteScore
6.70
自引率
2.60%
发文量
121
审稿时长
6-12 weeks
期刊介绍: This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on two topics, every issue of Current Opinion in Infectious Disease delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as HIV infection and AIDS; skin and soft tissue infections; respiratory infections; paediatric and neonatal infections; gastrointestinal infections; tropical and travel-associated diseases; and antimicrobial agents.
期刊最新文献
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