Increased cardiovascular disease risk among adolescents and young adults with gastric cancer.

IF 6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Gastric Cancer Pub Date : 2024-11-01 Epub Date: 2024-07-30 DOI:10.1007/s10120-024-01540-3
Hea Lim Choi, Danbee Kang, Hyunsoo Kim, Juhee Cho, Keun Hye Jeon, Wonyoung Jung, Dong Wook Shin, Su-Min Jeong
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Abstract

Background: Previous studies have investigated cardiovascular disease (CVD) risks in cancer patients, but there is limited knowledge concerning the CVD risk in adult and young adolescent (AYA) survivors of gastric cancer.

Objectives: This study aims to investigate the incidence of CVD in AYA gastric cancer survivors, analyzing it by treatment type and identifying associated risk factors.

Methods: We conducted a retrospective cohort study using Korean National Health Insurance Service data collected from 2006 to 2019. Propensity score matching (1:3, caliper < 0.1) was performed using the variables age, sex, income, residential area, and presence of comorbidities, and we classified participants into gastric cancer (n = 6562) and non-cancer control (n = 19,678) groups. Cox regression models were used to calculate hazard ratios (HRs) for CVD incidence. The study assessed CVD incidence by cancer treatment and identified risk factors through multivariable Cox regression.

Results: During a median 6.5-year follow-up, AYA gastric cancer survivors consistently exhibited greater CVD incidence. Their risk of CVD was significantly elevated compared to that of controls (HR, 1.18; 95% confidence interval [CI] 1.05-1.33). In particular, deep vein thrombosis (HR, 3.93; 95% CI 3.06-14.67) and pulmonary embolism (HR, 6.58; 95% CI 3.06-14.67) risks were notably increased. Chemotherapy was associated with an increased risk of stroke, heart failure, atrial fibrillation, deep vein thrombosis, and pulmonary embolism. Hypertension (HR, 1.58; 95% CI 1.10-2.26) and dyslipidemia (HR, 1.46; 95% CI 1.06-2.20) emerged as risk factors for CVD development.

Conclusion: This study reports elevated risks of CVD in AYA gastric cancer survivors and emphasizes the need for vigilant monitoring of CVD in this population.

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患有胃癌的青少年和年轻人患心血管疾病的风险增加。
背景:以往的研究对癌症患者的心血管疾病(CVD)风险进行了调查,但对成年和青少年胃癌幸存者的心血管疾病风险了解有限:本研究旨在调查青壮年胃癌幸存者的心血管疾病发病率,按治疗类型进行分析,并确定相关风险因素:我们使用韩国国民健康保险服务局从 2006 年至 2019 年收集的数据进行了一项回顾性队列研究。倾向得分匹配(1:3,卡尺在中位 6.5 年的随访期间,AYA 胃癌幸存者的心血管疾病发病率一直较高。与对照组相比,他们的心血管疾病风险明显升高(HR,1.18;95% 置信区间 [CI] 1.05-1.33)。尤其是深静脉血栓(HR,3.93;95% CI,3.06-14.67)和肺栓塞(HR,6.58;95% CI,3.06-14.67)的风险明显增加。化疗与中风、心力衰竭、心房颤动、深静脉血栓和肺栓塞的风险增加有关。高血压(HR,1.58;95% CI,1.10-2.26)和血脂异常(HR,1.46;95% CI,1.06-2.20)成为心血管疾病发生的风险因素:本研究报告了青壮年胃癌幸存者心血管疾病的高风险,并强调需要对这一人群的心血管疾病进行警惕性监测。
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来源期刊
Gastric Cancer
Gastric Cancer 医学-胃肠肝病学
CiteScore
14.70
自引率
2.70%
发文量
80
审稿时长
6-12 weeks
期刊介绍: Gastric Cancer is an esteemed global forum that focuses on various aspects of gastric cancer research, treatment, and biology worldwide. The journal promotes a diverse range of content, including original articles, case reports, short communications, and technical notes. It also welcomes Letters to the Editor discussing published articles or sharing viewpoints on gastric cancer topics. Review articles are predominantly sought after by the Editor, ensuring comprehensive coverage of the field. With a dedicated and knowledgeable editorial team, the journal is committed to providing exceptional support and ensuring high levels of author satisfaction. In fact, over 90% of published authors have expressed their intent to publish again in our esteemed journal.
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