Impact of preocular and ocular circulatory dynamics on the vascular density of retinal capillary plexuses and choriocapillaris.

IF 2.4 3区医学 Q2 OPHTHALMOLOGY Graefe’s Archive for Clinical and Experimental Ophthalmology Pub Date : 2024-12-01 Epub Date: 2024-07-31 DOI:10.1007/s00417-024-06544-4

Rodolphe Vallée, Dilsah Körpe, Jean-Noël Vallée, Georgios N Tsiropoulos, Daniela Gallo Castro, Irmela Mantel, Constantin J Pournaras, Aude Ambresin

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Abstract

Purpose: To highlight the influence of preocular and ocular vascular circulatory dynamics on the vascular density (VD) of retinal capillary plexuses (RCPs) and choriocapillaris (CC) in patients with and without cardiovascular risk (CVR) factors.

Methods: A retrospective observational study in patients with and without CVR factors (type 1 and 2 diabetes, arterial hypertension, and hypercholesterolemia). Fluorescein (FA) and indocyanine (ICGA) angiography circulatory times were arterial time (FA_AT), start (FA_startLF) and end (FA_endLF) of laminar flow, and arterial time (ICGA_AT), respectively. OCT angiography VDs were superficial (VD_SCP) and deep (VD_DCP) RCPs and CC (VD_CC) VDs. Correlation and regression analysis were performed after adjusting for confounding factors.

Results: 177 eyes of 177 patients (mean age: 65.2 ± 15.9 years, n = 92 with and 85 without CVR) were included. VD_SCP and VD_DCP were significantly inversely correlated with FA_AT, FA_startLF and FA_endLF likewise VD_CC with ICGA_AT. Correlations were stronger in patients without CVR than with CVR. CVR, FA_AT, FA_startLF and FA_endLF were more strongly correlated with VD_DCP than VD_SCP. FA_AT, FA_startLF and FA_endLF significantly impacted VD_SCP and VD_DCP, likewise ICGA_AT impacted VD_DCP. VD_DCP was most strongly impacted by FA_AT and FA_startLF.

Conclusion: Ocular and pre-ocular circulatory dynamics significantly impacted RCPs and CC VDs, especially deep RCP.

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眼前和眼球循环动力学对视网膜毛细血管丛和绒毛膜血管密度的影响。

目的：在存在和不存在心血管风险（CVR）因素的患者中，强调眼前和眼部血管循环动力学对视网膜毛细血管丛（RCP）和绒毛膜（CC）血管密度（VD）的影响：对有和无心血管风险因素（1 型和 2 型糖尿病、动脉高血压和高胆固醇血症）的患者进行回顾性观察研究。荧光素（FA）和吲哚菁（ICGA）血管造影循环时间分别为动脉时间（FAAT）、层流开始时间（FAstartLF）和结束时间（FAendLF）以及动脉时间（ICGAAT）。OCT 血管造影 VD 为浅层（VDSCP）和深层（VDDCP）RCP 和 CC（VDCC）VD。在调整了混杂因素后，进行了相关性和回归分析：结果：共纳入 177 名患者的 177 只眼睛（平均年龄：65.2 ± 15.9 岁，有 CVR 的 92 人和无 CVR 的 85 人）。VDSCP 和 VDDCP 与 FAAT、FAstartLF 和 FAendLF 呈显著反相关，同样，VDCC 与 ICGAAT 也呈显著反相关。无 CVR 患者的相关性强于有 CVR 的患者。CVR、FAAT、FAstartLF 和 FAendLF 与 VDDCP 的相关性比 VDSCP 更强。FAAT、FAstartLF 和 FAendLF 对 VDSCP 和 VDDCP 有显著影响，同样，ICGAAT 对 VDDCP 也有影响。FAAT 和 FAstartLF 对 VDDCP 的影响最大：结论：眼球和眼球前循环动力学对 RCP 和 CC VD 有重大影响，尤其是深部 RCP。

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来源期刊

Graefe’s Archive for Clinical and Experimental Ophthalmology 医学-眼科学

CiteScore

5.40

自引率

7.40%

发文量

398

审稿时长

3 months

期刊介绍： Graefe''s Archive for Clinical and Experimental Ophthalmology is a distinguished international journal that presents original clinical reports and clini-cally relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, Graefe''s Archive provides rapid dissemination of clinical and clinically related experimental information.