The Comparison of FLOT and DCF Regimens as Perioperative Treatment for Gastric Cancer.

IF 2.5 3区医学 Q3 ONCOLOGY Oncology Pub Date : 2024-07-30 DOI:10.1159/000540517

Gökhan Uçar, Serhat Sekmek, İrfan Karahan, Yakup Ergün, Özlem Aydın İsak, Sezai Tunç, Mutlu Doğan, Fatih Gürler, Doğan Bayram, Yusuf Açıkgöz, Selin Aktürk Esen, Burak Civelek, Fahriye Tuğba Köş, Öznur Bal, Efnan Algın, Tülay Eren, Gökşen İnanç İmamoğlu, Zuhat Urakçı, Ozan Yazıcı, Nuriye Özdemir, Doğan Uncu

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Abstract

Introduction: Locoregional gastric cancer is a still serious problem and perioperative treatments may improve the success of management. Different regimens were examined. The present study purposed to compare the efficacy of fluorouracil-leucovorin-oxaliplatin-docetaxel (FLOT) and docetaxel-cisplatin-fluorouracil (DCF) regimens.

Methods: A retrospective multicenter study assessed the patients with locoregional gastric cancer. There are 240 patients (137 DCF, 103 FLOT). Survival rates were compared.

Results: Demographic features were similar between the two groups, but the time period was different. The FLOT group had 7.8% pathological complete response, while the DCF group did not. Disease-free survival was longer in the FLOT than in the DCF group (median not reached - 13.94 months, respectively). Median overall survival was similar (30.9 vs. 37.8 months), but median follow-up affected the analysis. Survival for 36 months was 63% for the FLOT group and 40% for the DCF group (log-rank; p = 0.015).

Conclusion: FLOT regimen was superior to DCF regimen for response and survival rates. DCF is a historical approach. Long-term follow-up period is needed for FLOT treatment.

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FLOT和DCF疗法作为胃癌围手术期治疗方法的比较

导言局部胃癌仍然是一个严重的问题，围手术期治疗可提高治疗的成功率。人们对不同的治疗方案进行了研究。本研究旨在比较 FLOT 和 DCF 方案的疗效：回顾性多中心研究对局部胃癌患者进行了评估。共有 240 例患者（137 例 DCF，103 例 FLOT）。结果：两组患者的人口统计学特征相似：结果：两组患者的人口统计学特征相似，但时间段不同。FLOT组有7.8%的病理完全反应，而DCF组没有。FLOT组的无病生存期长于DCF组（中位数分别为13.94个月和13.94个月）。中位总生存期相似（30.9 个月对 37.8 个月），但中位随访时间影响了分析结果。FLOT组36个月的生存率为63%，DCF组为40%（P=0.015）：结论：在反应率和生存率方面，FLOT方案优于DCF方案。DCF是一种历史性方法。FLOT疗法需要长期随访。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncology 医学-肿瘤学

CiteScore

6.00

自引率

2.90%

发文量

审稿时长

6-12 weeks

期刊介绍： Although laboratory and clinical cancer research need to be closely linked, observations at the basic level often remain removed from medical applications. This journal works to accelerate the translation of experimental results into the clinic, and back again into the laboratory for further investigation. The fundamental purpose of this effort is to advance clinically-relevant knowledge of cancer, and improve the outcome of prevention, diagnosis and treatment of malignant disease. The journal publishes significant clinical studies from cancer programs around the world, along with important translational laboratory findings, mini-reviews (invited and submitted) and in-depth discussions of evolving and controversial topics in the oncology arena. A unique feature of the journal is a new section which focuses on rapid peer-review and subsequent publication of short reports of phase 1 and phase 2 clinical cancer trials, with a goal of insuring that high-quality clinical cancer research quickly enters the public domain, regardless of the trial’s ultimate conclusions regarding efficacy or toxicity.