Fangkun Zhang, Aozhe Meng, Yan Long, Zai-Qun Yu, Shuai Yu, Baoming Shan, Xue Z. Wang, Qilei Xu
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引用次数: 0
Abstract
Nucleation as a unique phenomenon in the crystallization process has always been a hot topic. With the development of nucleation theory and process analysis technology (PAT), nucleation control technology (NCT) has been widely applied in industrial crystallization processes. This paper provides a comprehensive review of advancements in nucleation measurement and control technologies within crystallization processes, systematically analyzing the principles, advantages, disadvantages, and application scopes of various NCTs, and particularly the factors affecting nucleation and nucleation-assisted technologies, including ultrasound, gassing, and membranes, are elaborated. These technologies are crucial for managing the unpredictable nature of nucleation to improve the consistency and quality of crystalline products. These advanced or novel control technologies are very attractive in providing continuous and stable high-purity seeds without externally adding additional seeds and have proven to be effective alternative methods for generating internal seeds. In addition, the challenges and opportunities were pointed out from the stability, controllability, and consistency of nucleation to promoting the efficient development of crystallization technology. NCTs play a vital role in industrial applications by ensuring control over the size, purity, and morphology of crystals. This review also explains the application of NCTs in industrial scenarios, positioning these technologies as essential for the advancement of various industrial applications.
期刊介绍：
The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.
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