Syzygium malaccense leaves methanol extract modulate some biochemical and inflammatory markers and prostate histology of testosterone-estradiol valerate induced benign prostatic hyperplasia in rats.

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI:10.22038/AJP.2023.23526
Ngozi Kalu Achi, Chinedum Ogbonnaya Eleazu, Chimaraoke Onyeabo, Winner Kalu, Kate Eleazu
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Abstract

Objective: The effect of Syzygium malaccense methanol leaf extract (SMLE) on some parameters of testosterone-estradiol valerate induced benign prostatic hyperplasia (BPH) in rats was assayed.

Materials and methods: Thirty male albino rats were used and they were grouped as: Control: received 1 mL/kg olive oil (oral and subcutaneous); BPH: received subcutaneously 9 mg/kg dihydrotestosterone (DHT)+0.9 mg/kg estradiol valerate (ESV) and orally 1 ml/kg olive oil; finasteride: received 9 mg/kg of DHT+0.9 mg/kg ESV (subcutaneously) and 5 mg/kg finasteride (orally) and test groups 1 and 2: received 9 mg/kg of DHT+0.9 mg/kg ESV (subcutaneously) and 200 and 400 mg/kg SMLE (orally). The duration of the treatment was 28 days.

Results: The BPH group had increased prostatic total proteins, oxidative stress, interleukin 8, tumor necrosis factor-α, prostate weights, serum concentrations of prostate specific antigen, estradiol, follicle stimulating hormone, and C-reactive protein, dyslipidaemia, altered prostate histology and hormonal levels but had no significant change (p>0.05) in haematological indices relative to the control. Finasteride or S. malaccense modulated most of these parameters as corroborated by prostate histology. Acute toxicity study indicated the non-toxicity of SMLE. SMLE showed strong in vitro antioxidant activity which corroborated its in vivo antioxidant activity.

Conclusion: The study showed that S. malaccense could be useful in the management of BPH.

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马钱子叶甲醇提取物可调节睾酮-戊酸雌二醇诱导的良性前列腺增生大鼠的一些生化指标、炎症指标和前列腺组织学。
目的:材料与方法:使用 30 只雄性白化大鼠,将其分为以下几组:对照组:口服和皮下注射 1 mL/kg 橄榄油;良性前列腺增生组:皮下注射 9 mg/kg 双氢睾酮(DHT)+0.9 mg/kg 戊酸雌二醇(ESV)和口服 1 ml/kg 橄榄油;非那雄胺组:口服 9 mg/kg DHT+0.9毫克/千克ESV(皮下注射)和5毫克/千克非那雄胺(口服);试验组1和2:接受9毫克/千克DHT+0.9毫克/千克ESV(皮下注射)和200和400毫克/千克SMLE(口服)。疗程为 28 天:结果:良性前列腺增生组的前列腺总蛋白、氧化应激、白细胞介素 8、肿瘤坏死因子-α、前列腺重量、前列腺特异性抗原、雌二醇、促卵泡激素和 C 反应蛋白的血清浓度、血脂异常、前列腺组织学和激素水平均有所增加,但血液学指标与对照组相比无显著变化(P>0.05)。前列腺组织学证实,非那雄胺或马钱子碱可调节这些参数中的大部分。急性毒性研究表明,SMLE 没有毒性。SMLE显示出很强的体外抗氧化活性,这也证实了其体内抗氧化活性:研究表明,S. malaccense可用于治疗良性前列腺增生症。
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来源期刊
Avicenna Journal of Phytomedicine
Avicenna Journal of Phytomedicine CHEMISTRY, MEDICINAL-
CiteScore
3.40
自引率
4.50%
发文量
17
审稿时长
6 weeks
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