Hydrophilic extract of Pistacia vera pericarp protects against phenylhydrazine-induced hepatotoxicity and hemolytic anemia.

IF 1.9 Q3 CHEMISTRY, MEDICINAL Avicenna Journal of Phytomedicine Pub Date : 2024-05-01 DOI:10.22038/AJP.2024.23925

Fatemeh Amin, Najmeh Parvaz, Nahid Askari, Morteza Khademalhosseini, Sakineh Khanamani Falahatipour, Iman Fatemi, Fatemeh Khajehasani, Zahra Taghipour, Soudeh Khanamani Falahati-Pour

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Abstract

Objective: Pistacia vera is commonly used in traditional medicine to treat various disorders. This study aims to investigate the anti-anemia and hepatoprotective effects of Pistacia vera pericarp extract (PVPE) in a rat model of phenylhydrazine (PHZ)-induced anemia.

Materials and methods: PVPE was prepared using the maceration method. The extract was administered at doses of 20, 80, and 160 mg/kg for 28 days to normal and PHZ-treated rats. The effects of PVPE were evaluated in terms of changes in biochemical, histological, hematological, and molecular biomarkers in the liver and blood.

Results: Administration of PVPE to the anemic animals significantly restored these deleterious effects on hematological parameters compared to the anemic group. Kupffer cell activation was seen in the liver tissue of the anemic rats. Administration of PVPE mitigated these deleterious effects.

Conclusion: PVPE has potent antioxidant activity and may represent a promising treatment for anemia and liver protection in clinical settings.

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Pistacia vera果皮的亲水提取物可防止苯肼引起的肝毒性和溶血性贫血。

目的：Pistacia vera 在传统医学中常用于治疗各种疾病。本研究旨在探讨Pistacia vera果皮提取物（PVPE）在苯肼（PHZ）诱导的大鼠贫血模型中的抗贫血和保肝作用：采用浸渍法制备 PVPE。以 20、80 和 160 毫克/千克的剂量给正常大鼠和 PHZ 处理过的大鼠服用 28 天。根据肝脏和血液中生化、组织学、血液学和分子生物标志物的变化，评估了 PVPE 的效果：结果：与贫血组相比，给贫血动物施用 PVPE 能明显恢复血液学参数的有害影响。贫血大鼠的肝组织中出现了 Kupffer 细胞活化。服用 PVPE 可减轻这些有害影响：结论：PVPE 具有强大的抗氧化活性，可能是临床上治疗贫血和保护肝脏的一种有效方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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