Phenotypic Heterogeneity in Pathogens.

IF 8.7 1区 生物学 Q1 GENETICS & HEREDITY Annual review of genetics Pub Date : 2024-07-31 DOI:10.1146/annurev-genet-111523-102459
Jessica Sherry, E Hesper Rego
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Abstract

Pathogen diversity within an infected organism has traditionally been explored through the lens of genetic heterogeneity. Hallmark studies have characterized how genetic diversity within pathogen subpopulations contributes to treatment escape and infectious disease progression. However, recent studies have begun to reveal the mechanisms by which phenotypic heterogeneity is established within genetically identical populations of invading pathogens. Furthermore, exciting new work highlights how these phenotypically heterogeneous subpopulations contribute to a pathogen population better equipped to handle the complex and fluctuating environment of a host organism. In this review, we focus on how bacterial pathogens, including Staphylococcus aureus, Salmonella typhimurium, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, establish and maintain phenotypic heterogeneity, and we explore recent work demonstrating causative links between this heterogeneity and infection outcome.

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病原体的表型异质性
受感染生物体内的病原体多样性历来是通过遗传异质性的视角来探讨的。标志性研究揭示了病原体亚群内的遗传多样性是如何导致治疗逃逸和传染病进展的。然而,最近的研究已开始揭示表型异质性是如何在基因相同的入侵病原体种群中建立起来的。此外,令人兴奋的新研究还强调了这些表型异质性亚群如何帮助病原体种群更好地应对宿主机体复杂多变的环境。在这篇综述中,我们将重点讨论包括金黄色葡萄球菌、伤寒沙门氏菌、铜绿假单胞菌和结核分枝杆菌在内的细菌病原体如何建立和维持表型异质性,并探讨最近证明这种异质性与感染结果之间因果关系的工作。
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来源期刊
Annual review of genetics
Annual review of genetics 生物-遗传学
CiteScore
18.30
自引率
0.90%
发文量
17
期刊介绍: The Annual Review of Genetics, published since 1967, comprehensively covers significant advancements in genetics. It encompasses various areas such as biochemical, behavioral, cell, and developmental genetics, evolutionary and population genetics, chromosome structure and transmission, gene function and expression, mutation and repair, genomics, immunogenetics, and other topics related to the genetics of viruses, bacteria, fungi, plants, animals, and humans.
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