RANDOMIZED EXPERIMENTAL STUDY OF TOPICAL VASODILATORS IN MICROSURGERY WITH COST ANALYSIS.

IF 0.5 4区医学 Q4 ORTHOPEDICS Acta Ortopedica Brasileira Pub Date : 2024-07-22 eCollection Date: 2024-01-01 DOI:10.1590/1413-785220243203e276513

Renato Polese Rusig, Debora Yumi Yoshimura Orlandin Alves, Amanda de Oliveira Silva Nascimento, Gustavo Bispo Dos Santos, Rames Mattar, Raquel Bernardelli Iamaguchi

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Abstract

Objective: Throughout microsurgical anastomosis, many surgeons use topical vasodilators in order to reduce pathological vasospasm. It was carried out an experimental study comparing the effectiveness of topical use of Nitroglycerin, Papaverine, Magnesium sulfate over a control group in the femoral artery and vein of rats, in reducing prolonged vasospasm.

Methods: Randomized comparative experimental study in 15 rats, divided into four groups. The external diameter of the vases soaked in the randomized solution was measured. For statistical analysis, it was calculated the percentual increase in the external diameter of the vessels.

Results: A statistically significant increase in arterial dilation was observed after 10 minutes of topical application of 10% magnesium sulfate compared to the control group, with p = 0.044 . No other drug showed a vasodilator effect superior to the control group. Magnesium sulfate at 10% is still not used in microsurgery and costs 15 times less than papaverine, the standard drug for topical vasodilation in clinical cases at our service.

Conclusion: Magnesium sulfate had better vasodilating effects over the control group after 10 minutes of arterial microanastomosis. None of the tested drugs have presented superior vasodilating effects over each other nor the control group after venous microanastomosis. Level of evidence II, Experimental study, Randomized Trial.

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显微手术中局部血管扩张剂的随机实验研究及成本分析。

目的：在显微外科吻合术中，许多外科医生会使用局部血管扩张剂，以减少病理性血管痉挛。我们进行了一项实验研究，比较在大鼠股动脉和静脉局部使用硝酸甘油、木蝴蝶碱和硫酸镁与对照组相比，在减少长时间血管痉挛方面的效果：方法：对 15 只大鼠进行随机比较实验研究，分为四组。测量浸泡在随机溶液中的花瓶的外径。为了进行统计分析，计算了血管外径增加的百分比：与对照组相比，局部使用 10%硫酸镁 10 分钟后观察到动脉扩张明显增加，P = 0.044。其他药物的血管扩张效果均不优于对照组。在显微外科手术中，10%硫酸镁的使用率还不高，而在我们的临床病例中，硫酸镁的价格比局部扩张血管的标准药物罂粟碱低 15 倍：结论：动脉微吻合术 10 分钟后，硫酸镁的血管扩张效果优于对照组。在静脉微吻合术后，没有一种受试药物的血管扩张效果优于其他药物或对照组。证据等级 II，实验研究，随机试验。

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来源期刊

Acta Ortopedica Brasileira Orthopedics-

CiteScore

0.90

自引率

14.30%

发文量

审稿时长

25 weeks

期刊介绍： A Revista Acta Ortopédica Brasileira, órgão oficial do Departamento de Ortopedia e Traumatologia da Faculdade de Medicina da Universidade de São Paulo (DOT/FMUSP), é publicada bimestralmente em seis edições ao ano (jan/fev, mar/abr, maio/jun, jul/ago, set/out e nov/dez) com versão em inglês disponível nos principais indexadores nacionais e internacionais e instituições de ensino do Brasil. Sendo hoje reconhecidamente uma importante contribuição para os especialistas da área com sua seriedade e árduo trabalho para as indexações já conquistadas.