O. O. Shichalin, O. V. Kapustina, Z. E. Kornakova, S. S. Gribanova, V. Y. Mayorov, A. N. Fedorets, A. O. Lembikov, V. V. Vasilyeva, I. Y. Buravlev, V. I. Apanasevich, E. K. Papynov
{"title":"Synthesis and Study of Sorption Properties of Ca3La6(SiO4)6 Biocomposite for Targeted Delivery of 5-Fluorouracil","authors":"O. O. Shichalin, O. V. Kapustina, Z. E. Kornakova, S. S. Gribanova, V. Y. Mayorov, A. N. Fedorets, A. O. Lembikov, V. V. Vasilyeva, I. Y. Buravlev, V. I. Apanasevich, E. K. Papynov","doi":"10.1134/s0036023624600412","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The dispersed Ca<sub>3</sub>La<sub>6</sub>(SiO<sub>4</sub>)<sub>6</sub> biocomposite was obtained by treating a calcium silicate sol containing 0.1, 0.3, and 0.7 mol of La<sup>3+</sup> under hydrothermal conditions. The composition, morphology, and structure of the biocomposite were studied by powder X-ray diffraction, SEM, and EDS methods. The reaction products (CaSiO<sub>3</sub>, CaLa<sub>4</sub>(SiO<sub>4</sub>)<sub>3</sub>O, Ca<sub>3</sub>La<sub>6</sub>(SiO<sub>4</sub>)<sub>6</sub>) depending on the La<sup>3+</sup> concentration were determined. The structural characteristics of biocomposite powders with different La<sup>3+</sup> contents were investigated by BET and DFT methods. The sorption characteristics of the materials towards 5-fluorouracil were studied depending on pH. The highest sorption capacity (0.768 mg/g at pH 3) was found for the Ca<sub>3</sub>La<sub>6</sub>(SiO<sub>4</sub>)<sub>6</sub> sample containing 0.3 mol of La<sup>3+</sup>. Additionally, the biocompatible properties of biocomposite samples in contact with artificial blood plasma were evaluated by establishing the key changes in their composition, morphology, and structure upon the formation of the apatite bioactive phase on the accessible surface of the samples. These results hold promise for further development of new sorption materials, including biomaterials, for targeted drug delivery with a potential for practical application.</p>","PeriodicalId":762,"journal":{"name":"Russian Journal of Inorganic Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Inorganic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1134/s0036023624600412","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
The dispersed Ca3La6(SiO4)6 biocomposite was obtained by treating a calcium silicate sol containing 0.1, 0.3, and 0.7 mol of La3+ under hydrothermal conditions. The composition, morphology, and structure of the biocomposite were studied by powder X-ray diffraction, SEM, and EDS methods. The reaction products (CaSiO3, CaLa4(SiO4)3O, Ca3La6(SiO4)6) depending on the La3+ concentration were determined. The structural characteristics of biocomposite powders with different La3+ contents were investigated by BET and DFT methods. The sorption characteristics of the materials towards 5-fluorouracil were studied depending on pH. The highest sorption capacity (0.768 mg/g at pH 3) was found for the Ca3La6(SiO4)6 sample containing 0.3 mol of La3+. Additionally, the biocompatible properties of biocomposite samples in contact with artificial blood plasma were evaluated by establishing the key changes in their composition, morphology, and structure upon the formation of the apatite bioactive phase on the accessible surface of the samples. These results hold promise for further development of new sorption materials, including biomaterials, for targeted drug delivery with a potential for practical application.
期刊介绍：
Russian Journal of Inorganic Chemistry is a monthly periodical that covers the following topics of research: the synthesis and properties of inorganic compounds, coordination compounds, physicochemical analysis of inorganic systems, theoretical inorganic chemistry, physical methods of investigation, chemistry of solutions, inorganic materials, and nanomaterials.
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