{"title":"The coupling of metabolic to secretory events in pancreatic islets: does hexose transport affect cationic fluxes?","authors":"W J Malaisse, M Mahy, A Sener","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Poorly metabolized hexoses, such as 3-O-methyl-D-glucose, 2-deoxy-D-glucose and D-galactose failed to reproduce the inhibition of 86Rb outflow, the early inhibition and secondary rise in 45Ca efflux and the stimulation of insulin release evoked by D-glucose in perifused rat islets. Insulin release induced by either D-glucose or 2-ketoisocaproate was also unaffected by 3-O-methyl-D-glucose. It is concluded that hexose transport in islet cells does not represent in itself a significant determinant of the cationic and secretory response to D-glucose.</p>","PeriodicalId":14735,"journal":{"name":"Journal de physiologie","volume":"83 1","pages":"32-5"},"PeriodicalIF":0.0000,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal de physiologie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Poorly metabolized hexoses, such as 3-O-methyl-D-glucose, 2-deoxy-D-glucose and D-galactose failed to reproduce the inhibition of 86Rb outflow, the early inhibition and secondary rise in 45Ca efflux and the stimulation of insulin release evoked by D-glucose in perifused rat islets. Insulin release induced by either D-glucose or 2-ketoisocaproate was also unaffected by 3-O-methyl-D-glucose. It is concluded that hexose transport in islet cells does not represent in itself a significant determinant of the cationic and secretory response to D-glucose.
代谢不良的己糖，如3- o -甲基-d -葡萄糖、2-脱氧-d -葡萄糖和d -半乳糖，未能在大鼠胰岛中重现86Rb流出的抑制、45Ca流出的早期抑制和继发性升高以及d -葡萄糖引起的胰岛素释放的刺激。d -葡萄糖或2-酮异己酸诱导的胰岛素释放也不受3- o -甲基- d -葡萄糖的影响。因此，胰岛细胞内己糖转运本身并不代表对d -葡萄糖的阳离子和分泌反应的重要决定因素。
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