Infectious Keratitis in Patients Over 65: A Review on Treatment and Preserving Eyesight

IF 3.6 3区医学 Clinical Interventions in Aging Pub Date : 2024-07-31 DOI:10.2147/cia.s467262

Christine K Kim, Melisa Z Karslioglu, Sharon H Zhao, Olivia L Lee

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Abstract

Abstract: Infectious keratitis (IK) represents a significant global health concern, ranking as the fifth leading cause of blindness worldwide despite being largely preventable and treatable. Elderly populations are particularly susceptible due to age-related changes in immune response and corneal structure. However, research on IK in this demographic remains scarce. Age-related alterations such as increased permeability and reduced endothelial cell density further compound susceptibility to infection and hinder healing mechanisms. Additionally, inflammaging, characterized by chronic inflammation that develops with advanced age, disrupts the ocular immune balance, potentially exacerbating IK and other age-related eye diseases. Understanding these mechanisms is paramount for enhancing IK management, especially in elderly patients. This review comprehensively assesses risk factors, clinical characteristics, and management strategies for bacterial, viral, fungal, and acanthamoeba keratitis in the elderly population, offering crucial insights for effective intervention.

Keywords: aging, inflammaging, bacterial keratitis, viral keratitis, fungal keratitis, acanthamoeba keratitis

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65 岁以上患者的感染性角膜炎：治疗和保护视力综述

摘要：传染性角膜炎（IK）是全球关注的重大健康问题，尽管在很大程度上可以预防和治疗，但它仍是全球第五大致盲原因。由于与年龄相关的免疫反应和角膜结构的变化，老年人群尤其容易受到感染。然而，针对这一人群的 IK 研究仍然很少。与年龄相关的变化，如渗透性增加和内皮细胞密度降低，进一步加剧了感染的易感性，并阻碍了愈合机制。此外，随着年龄的增长而出现的慢性炎症，破坏了眼部免疫平衡，可能会加重 IK 和其他与年龄相关的眼部疾病。了解这些机制对于加强 IK 的管理至关重要，尤其是对老年患者而言。这篇综述全面评估了老年人群中细菌性、病毒性、真菌性和棘阿米巴性角膜炎的危险因素、临床特征和管理策略，为有效干预提供了重要的见解。关键词：衰老、炎症、细菌性角膜炎、病毒性角膜炎、真菌性角膜炎、棘阿米巴性角膜炎

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来源期刊

Clinical Interventions in Aging GERIATRICS & GERONTOLOGY-

CiteScore

6.20

自引率

2.80%

发文量

193

期刊介绍： Clinical Interventions in Aging, is an online, peer reviewed, open access journal focusing on concise rapid reporting of original research and reviews in aging. Special attention will be given to papers reporting on actual or potential clinical applications leading to improved prevention or treatment of disease or a greater understanding of pathological processes that result from maladaptive changes in the body associated with aging. This journal is directed at a wide array of scientists, engineers, pharmacists, pharmacologists and clinical specialists wishing to maintain an up to date knowledge of this exciting and emerging field.