H+/X– Co‐Transport Driven by Azobenzene Containing Aromatic Amides

IF 3 4区 化学 Q3 CHEMISTRY, PHYSICAL ChemPhotoChem Pub Date : 2024-07-31 DOI:10.1002/cptc.202400179
Sameer Ahmad Malik, Nandita Madhavan
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Abstract

Natural ion‐transporters in cellular membranes play a critical role in maintaining cell homeostasis. Synthetic ion‐transporters are attractive model systems for understanding and addressing dysfunction of natural transporters. Herein, a simple amide derived from azobenzene and m‐aminobenzoic acid achieves photoregulated ion transport across lipid membranes. The amide forms pores or channels that selectively co‐transport H+/X– across the lipid membrane. Photoisomerization from the trans to cis form results in a 2‐fold increase in ion‐transport rates due to the higher proton affinity of the cis isomer.
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由含偶氮苯的芳香族酰胺驱动的 H+/X- 协同传输
细胞膜上的天然离子转运体在维持细胞平衡方面发挥着关键作用。合成离子转运体是了解和解决天然转运体功能障碍的极具吸引力的模型系统。在这里,一种由偶氮苯和间氨基苯甲酸衍生的简单酰胺实现了脂膜上的光调节离子转运。这种酰胺能形成孔隙或通道,选择性地共同传输 H+/X- 跨脂膜。由于顺式异构体的质子亲和力更高,因此从反式到顺式的光异构化会使离子传输速率提高 2 倍。
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来源期刊
ChemPhotoChem
ChemPhotoChem Chemistry-Physical and Theoretical Chemistry
CiteScore
5.80
自引率
5.40%
发文量
165
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