{"title":"Echinocytes in pyruvate kinase deficiency, post-splenectomy","authors":"Sarah A. Bassiony, Asad Luqmani, Barbara J. Bain","doi":"10.1002/ajh.27449","DOIUrl":null,"url":null,"abstract":"<p>Mitapivat has been shown in a randomized clinical trial to significantly improve hemoglobin levels and reduce transfusion requirements,<span><sup>3</sup></span> offering an improved quality of life, whilst also reducing the compounded risks associated with chronic transfusion in a young population.</p><p>The authors declare no conflict of interest.</p>","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"99 12","pages":"2379-2380"},"PeriodicalIF":10.1000,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ajh.27449","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Hematology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ajh.27449","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Mitapivat has been shown in a randomized clinical trial to significantly improve hemoglobin levels and reduce transfusion requirements,3 offering an improved quality of life, whilst also reducing the compounded risks associated with chronic transfusion in a young population.
期刊介绍：
The American Journal of Hematology offers extensive coverage of experimental and clinical aspects of blood diseases in humans and animal models. The journal publishes original contributions in both non-malignant and malignant hematological diseases, encompassing clinical and basic studies in areas such as hemostasis, thrombosis, immunology, blood banking, and stem cell biology. Clinical translational reports highlighting innovative therapeutic approaches for the diagnosis and treatment of hematological diseases are actively encouraged.The American Journal of Hematology features regular original laboratory and clinical research articles, brief research reports, critical reviews, images in hematology, as well as letters and correspondence.
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