Protective and therapeutic effects of nobiletin against cisplatin-induced nephrotoxicity in rats.

IF 1.6 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnic & Histochemistry Pub Date : 2024-08-02 DOI:10.1080/10520295.2024.2380663

Filiz Kazak, Pinar Coskun, Gul Fatma Yarim, Nuri Baspinar, Ozgur Ozdemir, Mehmet Burak Ates, Muhammed Enes Altug, Mehmet Zeki Yilmaz Deveci

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Abstract

Possible protective and therapeutic effects of nobiletin on kidney in a cisplatin-induced nephrotoxicity rat model were investigated. Forty male albino rats were divided into four groups: control, cisplatin (CIS), cisplatin+nobiletin (CIS+NOB), and nobiletin+cisplatin (NOB+CIS). At the end of the study, the rats were subjected to biochemical, histological and immunohistochemical analyzes. Compared to the control group, tGSH (p < 0.05) levels, and G6PD (p < 0.05) and GPx (p < 0.001) activities, were increased in the CIS group; while significant (p < 0.05) decreases occurred in the MDA and TOC levels. Histopathologically, the kidneys of the groups administered nobiletin (CIS+NOB, NOB+CIS) were significantly different from the CIS group, being closer to control group in terms of degeneration and hyaline cylinder formation in the tubules (p < 0.05). While dilatation in the tubules, protein-rich fluid and hyaline cylinder formation in the lumen were most common in the CIS group, a significant decrease (p < 0.05) of these parameters was seen in the nobiletin groups (CIS+NOB, NOB+CIS). This study suggests that nobiletin can be effective in preventing and ameliorating toxic effects of cisplatin on the kidney.

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金霉素对顺铂诱导的大鼠肾毒性的保护和治疗作用

在顺铂诱导的肾毒性大鼠模型中，研究了金没药对肾脏可能产生的保护和治疗作用。40 只雄性白化大鼠被分为四组：对照组、顺铂组（CIS）、顺铂+金霉素组（CIS+NOB）和金霉素+顺铂组（NOB+CIS）。研究结束后，对大鼠进行生化、组织学和免疫组化分析。与对照组相比，CIS 组的 tGSH（p < 0.05）水平、G6PD（p < 0.05）和 GPx（p < 0.001）活性均有所提高；而 MDA 和 TOC 水平则显著下降（p < 0.05）。从组织病理学角度看，服用金霉素组（CIS+NOB、NOB+CIS）的肾脏与 CIS 组有明显不同，在肾小管变性和透明圆柱形成方面更接近对照组（p < 0.05）。虽然 CIS 组最常见的是肾小管扩张、富含蛋白质的液体和管腔中透明圆柱的形成，但这些参数在 nobiletin 组（CIS+NOB、NOB+CIS）中明显减少（p < 0.05）。这项研究表明，金没药可有效预防和改善顺铂对肾脏的毒性作用。

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来源期刊

Biotechnic & Histochemistry 生物-生物工程与应用微生物

CiteScore

3.40

自引率

6.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Biotechnic & Histochemistry (formerly Stain technology) is the official publication of the Biological Stain Commission. The journal has been in continuous publication since 1926. Biotechnic & Histochemistry is an interdisciplinary journal that embraces all aspects of techniques for visualizing biological processes and entities in cells, tissues and organisms; papers that describe experimental work that employs such investigative methods are appropriate for publication as well. Papers concerning topics as diverse as applications of histochemistry, immunohistochemistry, in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, in vivo and in vitro studies, image analysis, cytogenetics, automation or computerization of investigative procedures and other investigative approaches are appropriate for publication regardless of their length. Letters to the Editor and review articles concerning topics of special and current interest also are welcome.