Cytotoxic evaluation of pure and doped iron oxide nanoparticles on cancer cells: a magnetic fluid hyperthermia perspective.

IF 3.6 3区 医学 Q3 NANOSCIENCE & NANOTECHNOLOGY Nanotoxicology Pub Date : 2024-08-01 Epub Date: 2024-08-02 DOI:10.1080/17435390.2024.2386019
Dharti Bhadla, Kinnari Parekh, Neeraj Jain
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Abstract

The need of the hour with respect to cancer treatment is a targeted approach with minimal or nil ramifications. Apropos, magnetic fluid hyperthermia (MFH) is emerging as a potential therapeutic strategy with anticipated reduced side effects for solid tumors. MFH causes cytotoxicity due to the heat generated owing to Hysteresis, Neel, and Brownian relaxation losses once magnetic nanoparticles (MNPs) carrying cancer cells are placed under an alternating magnetic field. With respect to MFH, iron oxide-based MNPs have been most extensively studied to date compared to other metal oxides with magnetic properties. The effectiveness of MFH relies on the composition, coating, size, physical and biocompatible properties of the MNPs. Pure iron oxide and doped iron oxide MNPs have been utilized to study their effects on cancer cell killing through MFH. This review evaluates the biocompatibility of pure and doped iron oxide MNPs and their subsequent hyperthermic effect for effectively killing cancer cells in vitro and in vivo.

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纯氧化铁纳米粒子和掺杂氧化铁纳米粒子对癌细胞的细胞毒性评估:磁流体热疗的视角。
癌症治疗的当务之急是采用一种有针对性的方法,将副作用降至最低或为零。因此,磁流体热疗(MFH)正成为一种潜在的治疗策略,可望减少对实体瘤的副作用。当携带癌细胞的磁性纳米粒子(MNPs)被置于交变磁场中时,由于磁滞、Neel 和布朗弛豫损失而产生的热量会导致细胞毒性。关于 MFH,与其他具有磁性的金属氧化物相比,迄今为止对氧化铁基 MNPs 的研究最为广泛。MFH 的有效性取决于 MNPs 的成分、涂层、尺寸、物理和生物相容性。纯氧化铁和掺杂氧化铁 MNPs 已被用于研究它们通过 MFH 杀死癌细胞的效果。本综述评估了纯氧化铁和掺杂氧化铁 MNPs 的生物相容性及其随后在体外和体内有效杀死癌细胞的热效应。
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来源期刊
Nanotoxicology
Nanotoxicology 医学-毒理学
CiteScore
10.10
自引率
4.00%
发文量
45
审稿时长
3.5 months
期刊介绍: Nanotoxicology invites contributions addressing research relating to the potential for human and environmental exposure, hazard and risk associated with the use and development of nano-structured materials. In this context, the term nano-structured materials has a broad definition, including ‘materials with at least one dimension in the nanometer size range’. These nanomaterials range from nanoparticles and nanomedicines, to nano-surfaces of larger materials and composite materials. The range of nanomaterials in use and under development is extremely diverse, so this journal includes a range of materials generated for purposeful delivery into the body (food, medicines, diagnostics and prosthetics), to consumer products (e.g. paints, cosmetics, electronics and clothing), and particles designed for environmental applications (e.g. remediation). It is the nano-size range if these materials which unifies them and defines the scope of Nanotoxicology . While the term ‘toxicology’ indicates risk, the journal Nanotoxicology also aims to encompass studies that enhance safety during the production, use and disposal of nanomaterials. Well-controlled studies demonstrating a lack of exposure, hazard or risk associated with nanomaterials, or studies aiming to improve biocompatibility are welcomed and encouraged, as such studies will lead to an advancement of nanotechnology. Furthermore, many nanoparticles are developed with the intention to improve human health (e.g. antimicrobial agents), and again, such articles are encouraged. In order to promote quality, Nanotoxicology will prioritise publications that have demonstrated characterisation of the nanomaterials investigated.
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