The Role of TGFBR3 in the Development of Lung Cancer.

IF 1 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Protein and Peptide Letters Pub Date : 2024-08-01 DOI:10.2174/0109298665315841240731060636

Xin Deng, Nuoya Ma, Junyu He, Fei Xu, Guoying Zou

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Abstract

The Transforming Growth Factor-β (TGF-β) mediates embryonic development, maintains cellular homeostasis, regulates immune function, and is involved in a wide range of other biological processes. TGF-β superfamily signaling pathways play an important role in cancer development and can promote or inhibit tumorigenesis. Type III TGF-β receptor (TGFBR3) is a co-receptor in the TGF-β signaling pathway, which often occurs with reduced or complete loss of expression in many cancer patients and can act as a tumor suppressor gene. The reduction or deletion of TGFBR3 is more pronounced compared to other elements in the TGF-β signaling pathway. In recent years, lung cancer is one of the major malignant tumors that endanger human health, and its prognosis is poor. Recent studies have reported that TGFBR3 expression decreases to varying degrees in different types of lung cancer, both at the tissue level and at the cellular level. The invasion, metastasis, angiogenesis, and apoptosis of lung cancer cells are closely related to the expression of TGFBR3, which strengthens the inhibitory function of TGFBR3 in the evolution of lung cancer. This article reviews the mechanism of TGFBR3 in lung cancer and the influencing factors associated with TGFBR3. Clarifying the physiological function of TGFBR3 and its molecular mechanism in lung cancer is conducive to the diagnosis and treatment of lung cancer.

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TGFBR3 在肺癌发展中的作用

转化生长因子-β（TGF-β）介导胚胎发育、维持细胞稳态、调节免疫功能，并参与其他多种生物过程。TGF-β 超家族信号通路在癌症发展中发挥着重要作用，可促进或抑制肿瘤发生。III 型 TGF-β 受体（TGFBR3）是 TGF-β 信号通路中的共受体，在许多癌症患者中经常出现表达减少或完全缺失的情况，可作为肿瘤抑制基因发挥作用。与 TGF-β 信号通路中的其他元素相比，TGFBR3 的减少或缺失更为明显。近年来，肺癌是危害人类健康的主要恶性肿瘤之一，且预后较差。最新研究报告显示，在不同类型的肺癌中，TGFBR3 的表达在组织水平和细胞水平均有不同程度的下降。肺癌细胞的侵袭、转移、血管生成和凋亡与TGFBR3的表达密切相关，这加强了TGFBR3在肺癌演变过程中的抑制作用。本文综述了TGFBR3在肺癌中的作用机制以及与TGFBR3相关的影响因素。阐明TGFBR3在肺癌中的生理功能及其分子机制有利于肺癌的诊断和治疗。

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来源期刊

Protein and Peptide Letters 生物-生化与分子生物学

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Protein & Peptide Letters publishes letters, original research papers, mini-reviews and guest edited issues in all important aspects of protein and peptide research, including structural studies, advances in recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, and drug design. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallization and preliminary structure determination of biologically important proteins are considered only if they include significant new approaches or deal with proteins of immediate importance, and preliminary structure determinations of biologically important proteins. Purely theoretical/review papers should provide new insight into the principles of protein/peptide structure and function. Manuscripts describing computational work should include some experimental data to provide confirmation of the results of calculations. Protein & Peptide Letters focuses on: Structure Studies Advances in Recombinant Expression Drug Design Chemical Synthesis Function Pharmacology Enzymology Conformational Analysis Immunology Biotechnology Protein Engineering Protein Folding Sequencing Molecular Recognition Purification and Analysis