In-hospital mortality and associated factors among patients admitted with venous thromboembolism at selected public hospitals of Harar Town, Eastern Ethiopia.

IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL SAGE Open Medicine Pub Date : 2024-07-30 eCollection Date: 2024-01-01 DOI:10.1177/20503121241266360
Dawit Abraham, Kirubel Minsamo Mishore, Shambel Nigussie, Abera Jambo, Tigist Gashaw
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Abstract

Background: Venous thromboembolism is the third most common cause of cardiovascular death and is responsible for more than 3 million deaths annually worldwide. Despite high rates of morbidity and mortality associated with venous thromboembolism, limited studies have been conducted on in-hospital mortality and its associated factors in Ethiopia, particularly in study settings.

Objective: To assess in-hospital mortality and associated factors among patients admitted with venous thromboembolism at selected public hospitals of Harar town, Eastern Ethiopia, from 10 March 2018 to 8 March 2022.

Methods: A retrospective cohort study design was conducted among 502 patients admitted with venous thromboembolism at Hiwot Fana Comprehensive Specialized Hospital and Jugal General Hospital using a simple random sampling technique. Data extraction formats were used to collect data from patient medical record cards. Then data were coded and entered into EpiData version 3.1 computer programs and exported to SPSS version 26 for analysis. Bivariate and multivariate backward Cox regression analysis was used to verify the associated factors of in-hospital mortality among venous thromboembolism patients. A p-value of less than 0.05 at a 95% confidence interval was used to establish a statistically significant association.

Results: A total of 502 patient medical record cards with outcome variables were included in the study. More than half of the patients 350 (69.7%) were females. Among the 502 patients who were admitted with venous thromboembolism, 8.2% (95% CI: 5.6-10.6) of patients had in-hospital mortality. DM (AHR = 4.28, 95% CI: 1.80-10.15, p = 0.001) and unfractionated heparin duration (AHR = 10.26, 95% CI: 2.45-43.01, p = 0.001) were statistically significant association with venous thromboembolism mortality.

Conclusion: Approximately 8.2% of venous thromboembolism patients died in the hospital. Diabetes and heparin were independently associated with higher mortality. Therefore, it is better to give more attention to the patients co-morbid with diabetes mellitus and for unfractionated heparin treatment duration to reduce venous thromboembolism mortality.

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埃塞俄比亚东部哈拉尔镇部分公立医院静脉血栓栓塞症住院患者的院内死亡率及相关因素。
背景:静脉血栓栓塞症是心血管疾病的第三大常见死因,每年造成全球 300 多万人死亡。尽管静脉血栓栓塞症的发病率和死亡率都很高,但在埃塞俄比亚,尤其是在研究环境中,关于院内死亡率及其相关因素的研究却很有限:评估2018年3月10日至2022年3月8日期间埃塞俄比亚东部哈拉尔镇部分公立医院收治的静脉血栓栓塞症患者的院内死亡率及相关因素:采用简单随机抽样技术,对Hiwot Fana综合专科医院和Jugal综合医院收治的502名静脉血栓栓塞症患者进行了回顾性队列研究。采用数据提取格式从患者病历卡中收集数据。然后将数据编码并输入 EpiData 3.1 版计算机程序,并导出到 SPSS 26 版进行分析。采用双变量和多变量逆向考克斯回归分析来验证静脉血栓栓塞症患者院内死亡率的相关因素。在95%的置信区间内,P值小于0.05即为具有统计学意义的关联:研究共纳入了 502 份包含结果变量的患者病历卡。350名患者中有一半以上(69.7%)为女性。在 502 名因静脉血栓栓塞入院的患者中,8.2%(95% CI:5.6-10.6)的患者有院内死亡。糖尿病(AHR = 4.28,95% CI:1.80-10.15,p = 0.001)和非丝裂霉素持续时间(AHR = 10.26,95% CI:2.45-43.01,p = 0.001)与静脉血栓栓塞死亡率有显著统计学关联:结论:约8.2%的静脉血栓栓塞症患者死于医院。糖尿病和肝素与较高的死亡率密切相关。因此,为了降低静脉血栓栓塞症的死亡率,最好对合并糖尿病的患者给予更多关注,并缩短非小量肝素的治疗时间。
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来源期刊
SAGE Open Medicine
SAGE Open Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
自引率
4.30%
发文量
289
审稿时长
12 weeks
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