Lower PHI, [-2]proPSA/fPSA and testosterone/estradiol ratios in healthy black men: preliminary results and potential implications in prostate cancer clinical management.

IF 4.9 2区 医学 Q1 UROLOGY & NEPHROLOGY Minerva Urology and Nephrology Pub Date : 2024-08-02 DOI:10.23736/S2724-6051.24.05667-2
Matteo Ferro, Ottavio DE Cobelli, Felice Crocetto, Gianluigi Carbone, Benito F Mirto, Mariano Fiorenza, Alfonso Falcone, Evelina LA Civita, Giuseppe Fallara, Gennaro Musi, Bernardo Rocco, Cristian Fiori, Francesco Porpiglia, Daniela Terracciano
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Abstract

Background: Black men residing in Western countries are more likely to develop prostate cancer (PCa), have higher mortality and are younger than the general population at initial diagnosis. In addition to genetic and environmental factors, the reasons for these racial disparities can also be attributed to social determinants of health such as low health literacy of this population and poor awareness of health services. Little is known about laboratory tests for PCa in black men.

Methods: In this preliminary study. we investigated whether ethnicity affect PSA molecular forms, PHI, estradiol and testosterone levels in healthy men.

Results: We found that healthy black men had lower PHI, [-2]proPSA/fPSA and testosterone/estradiol ratios.

Conclusions: Our findings even if on a small study population could have a relevant clinical impact. since PCa screening is particularly relevant in black men who are at high risk of clinically significant PCa. PSA-based screening is needed and overdiagnosis must be avoided. Our findings could be particularly impactful. Future research on larger population needs to consider whether ethnicity specific laboratory tests thresholds could help to reduce the ethnic inequalities in prostate cancer diagnosis.

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健康黑人男性较低的 PHI、[-2]proPSA/fPSA 和睾酮/雌二醇比率:初步结果及对前列腺癌临床管理的潜在影响。
背景:居住在西方国家的黑人男性患前列腺癌(PCa)的几率更高,死亡率也更高,而且初次确诊时比一般人群更年轻。除遗传和环境因素外,造成这些种族差异的原因还可归结为健康的社会决定因素,如该人群健康知识水平低和对医疗服务认识不足。人们对黑人男性 PCa 的实验室检测知之甚少:在这项初步研究中,我们调查了种族是否会影响健康男性的 PSA 分子形式、PHI、雌二醇和睾酮水平:结果:我们发现,健康黑人男性的 PHI、[-2]proPSA/fPSA 和睾酮/雌二醇比率较低:我们的研究结果即使只针对一小部分研究人群,也会产生相关的临床影响,因为 PCa 筛查对于临床上 PCa 风险较高的黑人男性尤为重要。需要进行基于 PSA 的筛查,同时必须避免过度诊断。我们的研究结果可能会产生特别大的影响。未来对更多人群的研究需要考虑特定种族的实验室检测阈值是否有助于减少前列腺癌诊断中的种族不平等。
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来源期刊
Minerva Urology and Nephrology
Minerva Urology and Nephrology UROLOGY & NEPHROLOGY-
CiteScore
8.50
自引率
32.70%
发文量
237
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