Homocysteine, blood pressure and gene-diet interactions in relation to vascular function measures of black South Africans.

IF 3.3 3区 医学 Q2 GENETICS & HEREDITY Genes and Nutrition Pub Date : 2024-08-01 DOI:10.1186/s12263-024-00751-8
Jacomina P du Plessis, Leandi Lammertyn, Aletta E Schutte, Cornelie Nienaber-Rousseau
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Abstract

Background and aims: We investigated circulating homocysteine (Hcy), a cardiovascular disease (CVD) risk factor, examining its dietary associations to provide personalized nutrition advice. This study addressed the inadequacy of current dietary interventions to ultimately address the disproportionately high incidence of CVD in Black populations.

Methods and results: Cross-sectional analyses of 1,867 Black individuals of the PURE-SA study allowed the identification of dietary intake and cardiovascular measure interactions on three sub-categories: (1) normal blood pressure (BP), hypertension or Hcy-related hypertension (H-type), (2) low, normal or high Hcy concentrations, and (3) Hcy-related genetic combinations. Favorable body composition, but adverse dietary intake and cardiovascular determinants, were observed in higher Hcy categories. H-types, compared to regular hypertensives, had higher alcohol and lower macronutrient and micronutrient consumption. Inverse associations with carotid-radial pulse wave velocity were evident between monounsaturated fatty acid (FA) consumption and H-type hypertension as well as polyunsaturated FA and CBS883/ins68 TT carriers. Energy intake was positively associated with vascular cell adhesion molecule-1 (VCAM-1) in variant CBST883C/ins68 and CBS9276 GG carriers. VCAM-1 was also positively associated with plant protein intake in CBS9276 GG and MTR2756 AA carriers and negatively with total protein intake and CBS9276 GG carriers. Alcohol intake was positively associated with intercellular adhesion molecule-1 in MTR2756 minor allele carriers.

Conclusion: Because Hcy gene-diet interactions are evident, personalized nutrition, by adjusting diets based on genetic profiles (e.g., CBS and MTR variations) and dietary interactions (e.g., FAs and proteins), can enhance cardiovascular outcomes by managing Hcy and related hypertension in genetically susceptible individuals.

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同型半胱氨酸、血压和基因-饮食相互作用与南非黑人血管功能测量的关系。
背景和目的:我们调查了心血管疾病(CVD)风险因素--循环同型半胱氨酸(Hcy),研究其与膳食的关系,以提供个性化的营养建议。这项研究探讨了目前的膳食干预措施不足以最终解决黑人心血管疾病发病率过高的问题:对 PURE-SA 研究中的 1867 名黑人进行横断面分析后,确定了膳食摄入量与心血管指标在三个子类别上的相互作用:(1)正常血压(BP)、高血压或 Hcy 相关高血压(H 型);(2)低、正常或高 Hcy 浓度;(3)Hcy 相关遗传组合。在 Hcy 较高的类别中,可以观察到有利的身体组成,但不利的饮食摄入和心血管决定因素。与普通高血压患者相比,H 型患者的酒精摄入量较高,宏量营养素和微量营养素摄入量较低。单不饱和脂肪酸(FA)摄入量与 H 型高血压以及多不饱和脂肪酸和 CBS883/ins68 TT 携带者之间存在明显的颈动脉径向脉搏波速度反向关系。在变异 CBST883C/ins68 和 CBS9276 GG 携带者中,能量摄入量与血管细胞粘附分子-1(VCAM-1)呈正相关。在 CBS9276 GG 和 MTR2756 AA 基因携带者中,VCAM-1 与植物蛋白摄入量呈正相关,而在 CBS9276 GG 基因携带者中,VCAM-1 与总蛋白摄入量呈负相关。在 MTR2756 小等位基因携带者中,酒精摄入量与细胞间粘附分子-1 呈正相关:结论:由于 Hcy 基因与膳食的相互作用非常明显,因此根据基因图谱(如 CBS 和 MTR 变异)和膳食相互作用(如脂肪酸和蛋白质)调整膳食,进行个性化营养,可通过控制遗传易感人群的 Hcy 和相关高血压,改善心血管预后。
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来源期刊
Genes and Nutrition
Genes and Nutrition 生物-遗传学
CiteScore
6.60
自引率
0.00%
发文量
14
审稿时长
6-12 weeks
期刊介绍: This journal examines the relationship between genetics and nutrition, with the ultimate goal of improving human health. It publishes original research articles and review articles on preclinical research data coming largely from animal, cell culture and other experimental models as well as critical evaluations of human experimental data to help deliver products with medically proven use.
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