Combination therapy increases human β-cell mass in vivo

IF 3.7 3区 医学 Q2 CHEMISTRY, MEDICINAL Chemical Research in Toxicology Pub Date : 2024-08-02 DOI:10.1038/s41574-024-01026-3
Olivia Tysoe
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联合疗法可增加体内人类 β 细胞的数量
与健康人相比,糖尿病患者的胰腺β细胞数量大幅减少。现在,《科学-转化医学》(Science Translational Medicine)杂志上的一项研究证明,双重酪氨酸调节激酶1A(DYRK1A)抑制剂与胰高血糖素样肽1(GLP1)受体激动剂联合治疗可有效增加体内人类β细胞的数量。研究人员将人类胰岛移植到免疫缺陷(Rag1-/-)小鼠的肾囊下。研究人员将人类胰岛移植到免疫缺陷小鼠(Rag1-/-)的肾脏囊下,并用药物对照组、哈米那、外泌丁4(一种GLP1受体激动剂)或哈米那和外泌丁4的组合(H&E)对这些小鼠进行长达3个月的治疗。"Garcia-Ocaña说:"我们采用了一种组织澄清技术和一种名为iDISCO+的光片显微镜方法,以三维方式观察肾囊下移植的人体小胰岛。
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来源期刊
CiteScore
7.90
自引率
7.30%
发文量
215
审稿时长
3.5 months
期刊介绍: Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.
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