Evaluation of Glymphatic System Development in Neonatal Brain via Diffusion Analysis along the Perivascular Space Index

IF 8.1 1区医学 Q1 CLINICAL NEUROLOGY Annals of Neurology Pub Date : 2024-08-03 DOI:10.1002/ana.27047

Shiwei Lin MS, Meifen Guo MS, Qunjun Liang PhD, Xiaoshan Lin MS, Shengli Chen MS, Ying Li MS, Peiqi Chen MS, Yingwei Qiu MD, PhD

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Abstract

Objective

Glymphatic system is a recently discovered macroscopic waste clearance system associated with numerous neurological diseases. However, little is known about glymphatic system development in neonates. We sought to evaluate diffusion along the perivascular space (ALPS) index, a proxy for glymphatic system function, in neonates and investigate its potential associations with maturation, sex, and preterm birth.

Methods

Diffusion magnetic resonance imaging (MRI) data in 418 neonates, including 92 preterm neonates (57 males) and 326 term neonates (175 males), from the Developing Human Connectome Project were used for evaluating ALPS index. Linear regression modeling was performed to assess group differences in the ALPS index according to preterm birth and sex. Pearson's and partial correlation analysis were performed to assess the association between the ALPS index and gestational age (GA) as well as postmenstrual age (PMA) at MRI. Moderation analysis was performed to assess the moderation effect of preterm birth on the relationship between the ALPS index and PMA.

Results

Compared to term neonates, preterm neonates exhibited lower ALPS indices (p < 0.001). The ALPS index positively correlated with PMA (p = 0.004) and GA (p < 0.001). Preterm birth (p = 0.013) had a significant moderation effect on the relationship between the ALPS index and PMA. Sex had no significant direct effect (p = 0.639) or moderation effect (p = 0.333) on ALPS index.

Interpretation

Glymphatic system development is a dynamic process in neonates, which can be moderated by preterm birth, the ALPS index could serve as a sensitive biomarker for monitoring this process. ANN NEUROL 2024;96:970–980

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通过沿血管周围空间指数的弥散分析评估新生儿脑内淋巴系统的发育情况

目的：淋巴系统是最近发现的一种与多种神经系统疾病相关的宏观废物清除系统。然而，人们对新生儿的淋巴系统发育知之甚少。我们试图评估新生儿沿血管周围空间的弥散（ALPS）指数，该指数可代表淋巴系统的功能，并研究其与成熟度、性别和早产的潜在关联：方法：利用发展中人类连接组项目（Developing Human Connectome Project）中 418 名新生儿的弥散磁共振成像（MRI）数据评估 ALPS 指数，其中包括 92 名早产新生儿（57 名男性）和 326 名足月新生儿（175 名男性）。通过线性回归模型来评估早产儿和性别在ALPS指数上的组间差异。为评估ALPS指数与妊娠年龄（GA）和核磁共振成像时的月经后年龄（PMA）之间的关系，进行了皮尔逊分析和偏相关分析。为了评估早产对ALPS指数和PMA之间关系的调节作用，还进行了调节分析：结果：与足月新生儿相比，早产新生儿的ALPS指数较低（p 解释：早产新生儿的ALPS指数低于足月新生儿：早产儿可以作为监测这一过程的敏感生物标志物。ann neurol 2024.

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来源期刊

Annals of Neurology 医学-临床神经学

CiteScore

18.00

自引率

1.80%

发文量

270

审稿时长

3-8 weeks

期刊介绍： Annals of Neurology publishes original articles with potential for high impact in understanding the pathogenesis, clinical and laboratory features, diagnosis, treatment, outcomes and science underlying diseases of the human nervous system. Articles should ideally be of broad interest to the academic neurological community rather than solely to subspecialists in a particular field. Studies involving experimental model system, including those in cell and organ cultures and animals, of direct translational relevance to the understanding of neurological disease are also encouraged.