Evolutionary neurogenomics at single-cell resolution

IF 3.7 2区 生物学 Q2 CELL BIOLOGY Current Opinion in Genetics & Development Pub Date : 2024-08-01 DOI:10.1016/j.gde.2024.102239
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Abstract

The human brain is composed of increasingly recognized heterogeneous cell types. Applying single-cell genomics to brain tissue can elucidate relative cell type proportions as well as differential gene expression and regulation among humans and other species. Here, we review recent studies that utilized high-throughput genomics approaches to compare brains among species at single-cell resolution. These studies identified genomic elements that are similar among species as well as evolutionary novelties on the human lineage. We focus on those human-relevant innovations and discuss the biological implications of these modifications. Finally, we discuss areas of comparative single-cell genomics that remain unexplored either due to needed technological advances or due to biological availability at the brain region or species level.

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单细胞分辨率的进化神经基因组学
人脑由越来越多被认可的异质细胞类型组成。将单细胞基因组学应用于脑组织可以阐明细胞类型的相对比例,以及人类和其他物种之间不同的基因表达和调控。在此,我们回顾了近期利用高通量基因组学方法以单细胞分辨率比较不同物种大脑的研究。这些研究发现了物种间相似的基因组元素以及人类血统的进化新特性。我们将重点关注这些与人类相关的创新,并讨论这些改变的生物学意义。最后,我们讨论了比较单细胞基因组学中尚未探索的领域,这些领域或是因为需要技术进步,或是因为大脑区域或物种水平的生物可用性。
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来源期刊
CiteScore
7.90
自引率
0.00%
发文量
102
审稿时长
1 months
期刊介绍: Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)
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