How obesity affects adipocyte turnover.

IF 11.4 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Trends in Endocrinology and Metabolism Pub Date : 2024-08-01 DOI:10.1016/j.tem.2024.07.004
Sang Mun Han, Hahn Nahmgoong, Kyung Min Yim, Jae Bum Kim
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Abstract

Cellular turnover is fundamental for tissue homeostasis and integrity. Adipocyte turnover, accounting for 4% of the total cellular mass turnover in humans, is essential for adipose tissue homeostasis during metabolic stress. In obesity, an altered adipose tissue microenvironment promotes adipocyte death. To clear dead adipocytes, macrophages are recruited and form a distinctive structure known as crown-like structure; subsequently, new adipocytes are generated from adipose stem and progenitor cells in the adipogenic niche to replace dead adipocytes. Accumulating evidence indicates that adipocyte death, clearance, and adipogenesis are sophisticatedly orchestrated during adipocyte turnover. In this Review, we summarize our current understandings of each step in adipocyte turnover, discussing its key players and regulatory mechanisms.

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肥胖是如何影响脂肪细胞周转的?
细胞更替是组织平衡和完整性的基础。脂肪细胞的新陈代谢占人类细胞新陈代谢总量的 4%,在新陈代谢压力下对脂肪组织的平衡至关重要。在肥胖症中,脂肪组织微环境的改变会促进脂肪细胞的死亡。为了清除死亡的脂肪细胞,巨噬细胞被招募进来并形成一种独特的结构,即冠状结构;随后,脂肪干细胞和祖细胞在脂肪生成龛中生成新的脂肪细胞,以取代死亡的脂肪细胞。越来越多的证据表明,在脂肪细胞更替过程中,脂肪细胞的死亡、清除和脂肪生成是复杂的协调过程。在这篇综述中,我们总结了目前对脂肪细胞更替过程中每个步骤的理解,讨论了其关键参与者和调控机制。
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来源期刊
Trends in Endocrinology and Metabolism
Trends in Endocrinology and Metabolism 医学-内分泌学与代谢
CiteScore
20.10
自引率
0.00%
发文量
98
审稿时长
82 days
期刊介绍: Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage. Explore recent advancements in diabetes, endocrine diseases, obesity, neuroendocrinology, immunometabolism, molecular and cellular biology, and a myriad of other areas through our journal. TEM serves as an invaluable resource for researchers, clinicians, lecturers, teachers, and students. Each monthly issue is anchored by Reviews and Opinion articles, with Reviews meticulously chronicling recent and significant developments, often contributed by leading researchers in specific fields. Opinion articles foster debate and hypotheses. Our shorter pieces include Science & Society, shedding light on issues at the intersection of science, society, and policy; Spotlights, which focus on exciting recent developments in the literature, and single-point hypotheses as Forum articles. We wholeheartedly welcome and encourage responses to previously published TEM content in the form of Letters.
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