The association between skeletal muscle mass and sensorineural hearing loss upon cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-08-02 DOI:10.1002/hed.27907

Anouk W M A Schaeffers, Anouk V M Burger, Charlotte W Duinkerken, Klaske E van Sluis, Jan Paul de Boer, Lisette van der Molen, Alex E Hoetink, Abrahim Al-Mamgani, Katarzyna Jóźwiak, Lot A Devriese, Remco de Bree, Charlotte L Zuur

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Abstract

Introduction: Patients with head and neck squamous cell carcinoma (HNSCC) treated with cisplatin-based chemoradiotherapy (CRT) frequently experience irreversible sensorineural hearing loss (SNHL). Patients with low lumbar skeletal muscle index (LSMI) may experience higher serum peak dosages of cisplatin. This study investigated whether pre-treatment low LSMI is associated with increased SNHL upon cisplatin-based CRT.

Materials and methods: LSMI was assessed using routine pre-treatment CT scans. Pure tone audiometry was performed at baseline and at follow-up to assess treatment-related SNHL. Linear mixed models were used to reveal a potential association between the continuous variable LSMI and SNHL.

Results: This retrospective cohort study included 81 patients and found a significant association between low LSMI and increased treatment-related SNHL at pure tone frequencies vital for the perception of speech (averaged of 1, 2, and 4 kHz) (p = 0.048).

Conclusions: HNSCC patients with low LSMI suffer increased treatment-related SNHL upon cisplatin-based CRT.

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头颈部鳞状细胞癌患者接受顺铂化放疗时骨骼肌质量与感音神经性听力损失之间的关系。

简介：头颈部鳞状细胞癌（HNSCC）患者在接受以顺铂为基础的化放疗（CRT）治疗后，经常会出现不可逆的感音神经性听力损失（SNHL）。腰部骨骼肌指数（LSMI）较低的患者血清中顺铂的峰值剂量可能较高。本研究调查了治疗前低LSMI是否与基于顺铂的CRT时SNHL的增加有关：使用治疗前常规 CT 扫描评估 LSMI。在基线和随访时进行纯音测听，以评估与治疗相关的SNHL。线性混合模型用于揭示连续变量 LSMI 与 SNHL 之间的潜在联系：这项回顾性队列研究纳入了 81 名患者，发现在对言语感知至关重要的纯音频率（1、2 和 4 kHz 的平均值）上，低 LSMI 与治疗相关 SNHL 增加之间存在显著关联（p = 0.048）：结论：低LSMI的HNSCC患者在接受以顺铂为基础的CRT治疗时，与治疗相关的SNHL会增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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