Additive-Free Commercial Alumina Catalyzes the Halogen Exchange Reaction of Long Alkyl Halides in Batch and in Flow Processes

IF 3.3 Q2 CHEMISTRY, MULTIDISCIPLINARY ACS Organic & Inorganic Au Pub Date : 2024-08-02 DOI:10.1021/acsorginorgau.4c00039
Paloma Mingueza-Verdejo, Susi Hervàs-Arnandis, Judit Oliver-Meseguer, Antonio Leyva-Pérez
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引用次数: 0

Abstract

The synthesis of alkyl halides can be performed by simply halide exchange reactions between two different alkyl halides, catalyzed by aluminosilicates. Here, we show that commercially available alumina shows a superior catalytic activity for the halogen exchange reaction between long alkyl halides (more than 6 carbons), including fluorides, in either batch or flow modes. The catalytic activity of the solid alumina is modulated by alkaline countercations on the surface, and sodium-supported alumina shows the optimal performance for the iodo-bromo and iodo-fluoro exchange under inflow reaction conditions, after >24 h reaction time, without any external additive.
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无添加剂商用氧化铝在间歇式和流动式工艺中催化长烷基卤化物的卤素交换反应
烷基卤化物的合成可以通过两种不同烷基卤化物在铝硅酸盐催化下进行简单的卤素交换反应来实现。在此,我们展示了市售氧化铝在间歇或流动模式下,对包括氟化物在内的长烷基卤化物(超过 6 个碳原子)之间的卤素交换反应具有卓越的催化活性。固体氧化铝的催化活性受表面碱性反阳离子的调节,钠支持的氧化铝在流入反应条件下,经过>24小时的反应时间后,在不使用任何外部添加剂的情况下,显示出最佳的碘溴和碘氟交换性能。
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来源期刊
ACS Organic & Inorganic Au
ACS Organic & Inorganic Au 有机化学、无机化学-
CiteScore
4.10
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0.00%
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0
期刊介绍: ACS Organic & Inorganic Au is an open access journal that publishes original experimental and theoretical/computational studies on organic organometallic inorganic crystal growth and engineering and organic process chemistry. Short letters comprehensive articles reviews and perspectives are welcome on topics that include:Organic chemistry Organometallic chemistry Inorganic Chemistry and Organic Process Chemistry.
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