Taurine exhibits antioxidant, anti-inflammatory, and antiapoptotic effects against pyraclostrobin exposure in rats.

IF 2.2 4区医学 Q3 TOXICOLOGY Toxicology Research Pub Date : 2024-08-02 eCollection Date: 2024-08-01 DOI:10.1093/toxres/tfae120

Ibrahim Serim, Hasan Huseyin Demirel, Fahriye Zemheri-Navruz, Sinan Ince

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Abstract

Pyraclostrobin, a strobilurin-derived fungicide, causes oxidative stress and DNA damage in the organism. Taurine plays an important role in metabolic processes such as osmoregulatory, cytoprotective, and antioxidant effects. The study aimed to investigate the protective effect of taurine in Sprague Dawley male rats exposed to pyraclostrobin. The rats were separated into 6 groups and were found 8 animals in each group. Rats were given 30 mg/kg pyraclostrobin and pyraclostrobin together with three different taurine concentrations (50, 100, and 200 mg/kg) via oral gavage for 28 days. While pyraclostrobin increased biochemical parameters, lipid peroxidation, and DNA damage, it decreased glutathione levels and enzyme activities of catalase and superoxide dismutase. Pyraclostrobin increased apoptotic, proinflammatory, and CYP2E1 mRNA expression levels, whereas antiapoptotic gene Bcl-2 mRNA expression levels decreased in liver tissue. Additionally, pyraclostrobin caused histopathological alterations in tissues. Taurine in a dose-dependent manner reversed the changes caused by pyraclostrobin. As a result, taurine exhibited a cytoprotective effect by showing antioxidant, anti-inflammatory, and antiapoptotic activities against oxidative damage caused by pyraclostrobin.

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牛磺酸对暴露于吡唑醚菌酯的大鼠具有抗氧化、抗炎和抗细胞凋亡作用。

Pyraclostrobin 是一种源自strobilurin的杀真菌剂，会对生物体造成氧化应激和 DNA 损伤。牛磺酸在代谢过程中发挥着重要作用，如渗透调节、细胞保护和抗氧化作用。本研究旨在调查牛磺酸对暴露于吡唑醚菌酯的 Sprague Dawley 雄性大鼠的保护作用。大鼠被分为 6 组，每组 8 只。通过口服给大鼠灌胃 30 毫克/千克的吡唑醚菌酯和吡唑醚菌酯以及三种不同浓度的牛磺酸（50、100 和 200 毫克/千克），持续 28 天。虽然吡唑醚菌酯会增加生化指标、脂质过氧化和 DNA 损伤，但会降低谷胱甘肽水平以及过氧化氢酶和超氧化物歧化酶的酶活性。吡唑醚菌酯增加了肝组织中凋亡、促炎和 CYP2E1 mRNA 的表达水平，而抗凋亡基因 Bcl-2 mRNA 的表达水平下降。此外，吡唑醚菌酯还会导致组织病理学改变。牛磺酸以剂量依赖的方式逆转了吡唑醚菌酯引起的变化。因此，牛磺酸具有抗氧化、抗炎和抗细胞凋亡活性，对吡唑醚菌酯引起的氧化损伤具有细胞保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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