Myelofibrosis and anemia: A German claims data analysis to describe epidemiology and current treatment

IF 2.3 3区 医学 Q2 HEMATOLOGY European Journal of Haematology Pub Date : 2024-08-05 DOI:10.1111/ejh.14284
Alexander Slowley, Sofie Weinmann, Tim d'Estrube, Kelesitse Phiri, Florian M. Karl, Erika Gleißner, Sabrina Mueller, Sophia Junker, Joachim R. Göthert
{"title":"Myelofibrosis and anemia: A German claims data analysis to describe epidemiology and current treatment","authors":"Alexander Slowley,&nbsp;Sofie Weinmann,&nbsp;Tim d'Estrube,&nbsp;Kelesitse Phiri,&nbsp;Florian M. Karl,&nbsp;Erika Gleißner,&nbsp;Sabrina Mueller,&nbsp;Sophia Junker,&nbsp;Joachim R. Göthert","doi":"10.1111/ejh.14284","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>There is limited data on the incidence, prevalence, and treatments for myelofibrosis (MF) in Germany. This retrospective study examined claims data from 3.3 million insured individuals, spanning from 2010 to 2021.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Four sensitivity scenarios were explored to identify cases of MF. Point prevalence and cumulative incidence of MF were determined as of December 31, 2021, and within 2021, respectively. A cross-sectional analysis used the main scenario definition of MF to identify cases and evaluate the period prevalence of patients receiving treatment for symptoms and/or splenomegaly, including first-line (1L) Janus kinase inhibitor (JAKi), second-line, or further (2L+) MF-related treatment therapies during 2021. The prevalence of anemia treatment was also reported.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The estimated standardized point prevalence of MF on December 31, 2021, was 9.9–12.4 cases per 100 000 persons, and cumulative incidence in 2021 was 1.2–1.8 cases per 100 000 persons. Standardized period prevalence in 2021 for MF patients receiving 1L JAKi and/or 2L+ MF-related treatment was 4.0 cases per 100 000. Among these patients, 47.1%–53.7% required treatment for anemia, resulting in a period prevalence of 1.9–2.2 cases per 100 000 individuals.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The data reveal gaps in MF treatments and the need to improve patient quality of life.</p>\n </section>\n </div>","PeriodicalId":11955,"journal":{"name":"European Journal of Haematology","volume":"113 5","pages":"704-715"},"PeriodicalIF":2.3000,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejh.14284","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Haematology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ejh.14284","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Objectives

There is limited data on the incidence, prevalence, and treatments for myelofibrosis (MF) in Germany. This retrospective study examined claims data from 3.3 million insured individuals, spanning from 2010 to 2021.

Methods

Four sensitivity scenarios were explored to identify cases of MF. Point prevalence and cumulative incidence of MF were determined as of December 31, 2021, and within 2021, respectively. A cross-sectional analysis used the main scenario definition of MF to identify cases and evaluate the period prevalence of patients receiving treatment for symptoms and/or splenomegaly, including first-line (1L) Janus kinase inhibitor (JAKi), second-line, or further (2L+) MF-related treatment therapies during 2021. The prevalence of anemia treatment was also reported.

Results

The estimated standardized point prevalence of MF on December 31, 2021, was 9.9–12.4 cases per 100 000 persons, and cumulative incidence in 2021 was 1.2–1.8 cases per 100 000 persons. Standardized period prevalence in 2021 for MF patients receiving 1L JAKi and/or 2L+ MF-related treatment was 4.0 cases per 100 000. Among these patients, 47.1%–53.7% required treatment for anemia, resulting in a period prevalence of 1.9–2.2 cases per 100 000 individuals.

Conclusion

The data reveal gaps in MF treatments and the need to improve patient quality of life.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
骨髓纤维化和贫血:德国索赔数据分析,描述流行病学和当前治疗情况。
目的:有关德国骨髓纤维化(MF)的发病率、流行率和治疗方法的数据十分有限。这项回顾性研究检查了 330 万投保人的理赔数据,时间跨度为 2010 年至 2021 年:方法:探讨了四种敏感性情景,以确定骨髓纤维化病例。分别确定了截至 2021 年 12 月 31 日和 2021 年内的 MF 点流行率和累积发病率。横断面分析使用 MF 的主要情景定义来确定病例,并评估 2021 年期间因症状和/或脾肿大而接受治疗(包括一线 (1L) Janus 激酶抑制剂 (JAKi)、二线或进一步 (2L+) MF 相关治疗疗法)的患者的期间患病率。此外,还报告了贫血治疗的流行率:结果:2021年12月31日的MF标准化点患病率估计为每10万人9.9-12.4例,2021年的累计发病率为每10万人1.2-1.8例。2021 年,接受 1L JAKi 和/或 2L+ MF 相关治疗的 MF 患者的标准化时期发病率为每 10 万人 4.0 例。在这些患者中,47.1%-53.7%的人需要接受贫血治疗,因此每10万人中的患病率为1.9-2.2例:结论:这些数据揭示了骨髓纤维化治疗方面的差距,以及提高患者生活质量的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
5.50
自引率
0.00%
发文量
168
审稿时长
4-8 weeks
期刊介绍: European Journal of Haematology is an international journal for communication of basic and clinical research in haematology. The journal welcomes manuscripts on molecular, cellular and clinical research on diseases of the blood, vascular and lymphatic tissue, and on basic molecular and cellular research related to normal development and function of the blood, vascular and lymphatic tissue. The journal also welcomes reviews on clinical haematology and basic research, case reports, and clinical pictures.
期刊最新文献
TP53 Mutation Is the Only Robust Mutational Biomarker for Outcome Found in a Consecutive Clinical Cohort of Real-Word Patients With Primary Large B-Cell Lymphoma. Direct Oral Anticoagulants in Budd-Chiari Syndrome. BAY 81-8973 Demonstrates Long-Term Safety and Efficacy in Children With Severe Haemophilia A: Results From the LEOPOLD Kids Extension Study. The Effect of the Pre-Transplant Disease Status on the Outcome for Recipients of T-Cell Depleted Allogeneic Haematopoietic Stem Cell Transplants for Large B Cell Lymphomas. Secondary Malignancies After Autologous Stem Cell Transplantations in Patients With Malignant Lymphoma and Multiple Myeloma.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1