Usefulness of dalbavancin in early discharge and nonhospitalization. It's time to throw your heart over the obstacle?

IF 0.4 Q4 HEALTH CARE SCIENCES & SERVICES Global & Regional Health Technology Assessment Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI:10.33393/grhta.2024.3071
Massimo Crapis, Sergio Venturini, Astrid Callegari, Giovanni Del Fabro, Igor Bramuzzo, Laura De Santi, Elisa Pontoni, Maurizio Tonizzo, Barbara Basso
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Abstract

Introduction: Dalbavancin is a semisynthetic lipoglycopeptide long-acting antibiotic approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs). Its features can be useful in the current healthcare scenario characterized by the shortage of available hospital beds.

Materials methods and results: We implemented several actions in order to optimize the use of dalbavancin allowing an improvement strategy both from the healthcare system and the patient's perspective in two hospital settings. In the Emergency Department we hospitalized only patients who met the clinical criteria and not the logistic criteria (i.e., the need for antibiotic therapy infusion). During the years 2017-2023, this strategy was applied in 40 cases, thus avoiding 40 hospitalizations for a total saving of 280 days of hospitalization.In the Internal Medicine ward and surgery department when there was no longer any need for hospitalization, we discharged the patient as early as possible. During the years 2017-2023, this strategy was applied in 189 cases, saving at least 1,134 days of hospitalization. The outcome of the treated patients was favorable in 228 out of 229 patients (99.5%).

Conclusions: Our experience using dalbavancin in ABSSSI has been very satisfactory overall. The efficacy was close to 100%. Minor adverse events of slight severity occurred rarely. At the same time, this strategy allowed a more efficient allocation of hospital beds. Dalbavancin presents an ideal pharmacodynamic/pharmacokinetic profile for the management of ABSSSI especially in settings where shortage of hospital beds is critical.

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达巴万星在早期出院和非住院治疗中的作用。是时候把心扔到障碍物上了吗?
简介达尔巴万星(Dalbavancin)是一种半合成脂甘肽类长效抗生素,已被批准用于治疗急性细菌性皮肤和皮肤结构感染(ABSSSIs)。在当前病床短缺的医疗环境下,它的特点非常有用:我们采取了多项措施来优化达巴万星的使用,以便从医疗系统和患者的角度出发,在两家医院实施改进策略。在急诊科,我们只让符合临床标准而非逻辑标准(即需要输注抗生素治疗)的患者住院。在 2017-2023 年间,这一策略应用于 40 个病例,从而避免了 40 次住院,共节省 280 天住院时间。在内科病房和外科病房,当不再需要住院治疗时,我们会让患者尽早出院。2017-2023年间,这一策略共应用于189例患者,至少节省了1134天的住院时间。在 229 例患者中,228 例(99.5%)的治疗结果良好:我们使用达巴万星治疗 ABSSSI 的经验总体上非常令人满意。疗效接近 100%。极少发生轻微不良反应。同时,这种策略还能更有效地分配病床。达尔巴万星具有理想的药效学/药代动力学特征,可用于治疗 ABSSSI,尤其是在医院床位紧缺的情况下。
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来源期刊
Global & Regional Health Technology Assessment
Global & Regional Health Technology Assessment HEALTH CARE SCIENCES & SERVICES-
CiteScore
0.80
自引率
20.00%
发文量
27
审稿时长
8 weeks
期刊介绍: Global & Regional Health Technology Assessment (GRHTA) is a peer-reviewed, open access journal which aims to promote health technology assessment and economic evaluation, enabling choices among alternative therapeutical paths or procedures with different clinical and economic outcomes. GRHTA is a unique journal having three different editorial boards who focus on their respective geographical expertise.
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