Associations of the PPARα and Lipoprotein Lipase Enzyme Gene Polymorphisms with Dyslipidemia in Obese and Non-obese Males.

IF 4.7 Q1 ENDOCRINOLOGY & METABOLISM Journal of Obesity & Metabolic Syndrome Pub Date : 2024-09-30 Epub Date: 2024-08-05 DOI:10.7570/jomes23064
Rithab Ibrahim Al-Samawi, Thekra A Al-Kashwan, Abdul Hussein A Algenabi
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Abstract

Background: Peroxisome proliferator-activated receptor α (PPARα) is a nuclear transcription factor responsible for gene expression, particularly those associated with lipid metabolism. The lipoprotein lipase enzyme (LPL) is considered a key enzyme in lipid metabolism and transport. The link between dyslipidemia and obesity is well understood. Dyslipidemia is also an established risk feature for cardiovascular disease. Thus, it becomes progressively essential to identify the role of genetic factors as risk markers for the development of dyslipidemia among obese males.

Methods: A case-control study was performed including 469 males. Anthropometric characteristics and serum lipid profiles such as triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were evaluated. Genomic DNA extraction and purification were performed using whole blood samples. Restriction enzyme fragment length polymorphism was used to genotype PPARα and LPL single nucleotide polymorphisms. The associations between these polymorphisms and dyslipidemia were examined.

Results: The CC and CG genotypes of PPARα gene polymorphisms were significantly associated with higher TC and LDL-C levels (P<0.05). The TT genotype of the LPL gene polymorphism was significantly associated with higher TG levels and lower HDL-C levels (P<0.05). In contrast, the GG genotype may have a protective action against dyslipidemia.

Conclusion: The study reaches the interesting conclusion that there was a significant association between PPARα as well as LPL gene polymorphisms and dyslipidemia among obese and non-obese males.

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肥胖和非肥胖男性 PPARα 和脂蛋白脂酶基因多态性与血脂异常的关系
背景:过氧化物酶体增殖激活受体α(PPARα)是一种核转录因子,负责基因表达,尤其是与脂质代谢相关的基因表达。脂蛋白脂肪酶(LPL)被认为是脂质代谢和运输的关键酶。血脂异常与肥胖之间的联系已广为人知。血脂异常也是心血管疾病的既定风险特征。因此,确定遗传因素作为肥胖男性血脂异常风险标志物的作用变得越来越重要:方法:对 469 名男性进行了病例对照研究。方法:对 469 名男性进行了一项病例对照研究,评估了他们的人体测量特征和血清脂质概况,如甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)。使用全血样本进行基因组 DNA 提取和纯化。利用限制性酶片段长度多态性对 PPARα 和 LPL 单核苷酸多态性进行基因分型。结果表明,PPARα和LPL单核苷酸多态性的CC和CG基因型与血脂异常之间的关系密切:结果:PPARα基因多态性的CC和CG基因型与较高的TC和LDL-C水平显著相关(PPC结论:PPARα基因多态性的CC和CG基因型与较高的TC和LDL-C水平显著相关:该研究得出了一个有趣的结论:在肥胖和非肥胖男性中,PPARα和LPL基因多态性与血脂异常之间存在明显的关联。
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来源期刊
Journal of Obesity & Metabolic Syndrome
Journal of Obesity & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-
CiteScore
8.30
自引率
9.60%
发文量
39
审稿时长
19 weeks
期刊介绍: The journal was launched in 1992 and diverse studies on obesity have been published under the title of Journal of Korean Society for the Study of Obesity until 2004. Since 2017, volume 26, the title is now the Journal of Obesity & Metabolic Syndrome (pISSN 2508-6235, eISSN 2508-7576). The journal is published quarterly on March 30th, June 30th, September 30th and December 30th. The official title of the journal is now "Journal of Obesity & Metabolic Syndrome" and the abbreviated title is "J Obes Metab Syndr". Index words from medical subject headings (MeSH) list of Index Medicus are included in each article to facilitate article search. Some or all of the articles of this journal are included in the index of PubMed, PubMed Central, Scopus, Embase, DOAJ, Ebsco, KCI, KoreaMed, KoMCI, Science Central, Crossref Metadata Search, Google Scholar, and Emerging Sources Citation Index (ESCI).
期刊最新文献
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