Prognostic impact of liver resection side in peri-hilar cholangiocarcinoma: A systematic review and meta-analysis

IF 2.3 4区医学 Q3 ONCOLOGY Surgical Oncology-Oxford Pub Date : 2024-07-31 DOI:10.1016/j.suronc.2024.102113

Cecilio Armengol-García , Valeria Blandin-Alvarez , David Eugenio Hinojosa-Gonzalez , Eduardo Flores-Villalba

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Abstract

Background

Perihilar cholangiocarcinoma (pCCA) is a highly lethal hepatobiliary cancer. Radical resection offers the best chance for extended survival, but the efficacy of left-sided hepatectomy (LH) versus right-sided hepatectomy (RH) remains controversial.

Methods

A systematic review and meta-analysis of non-randomized cohort studies comparing LH and RH in patients with resectable pCCA was conducted. Subanalyses were performed based on year of publication, region, number of cases and Bismuth classification (BC) ≥ III.

Results

Nineteen studies involving 3838 patients were included, with 1779 (46 %) undergoing LH and 2059 (54 %) undergoing RH. LH was associated with increased overall survival (OS) in subgroup analysis of studies reporting hazard ratios (HR) (logHR 0.59; p = 0.04). LH showed higher rates of arterial resection (14 % vs. 1 %), transfusion (51 % vs. 41 %), operation time (MD 31.44 min), and bile leakage (21 % vs. 18 %), but lower rates of post-hepatectomy liver failure (9 % vs. 21 %) and 90-day mortality (8 % vs 16 %). Three-year disease-free survival rates increased in Western centers but decreased in Eastern centers.

Conclusion

LH is linked to higher OS in this analysis but is a more demanding technique. Resection side decision should consider several factors, including future liver remnant, tumor location, vascular involvement, and surgical expertise.

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肝门周围胆管癌肝切除侧的预后影响：系统综述和荟萃分析。

背景：肝周胆管癌（pCCA）是一种致死率极高的肝胆癌。根治性切除术为延长生存期提供了最佳机会，但左侧肝切除术（LH）与右侧肝切除术（RH）的疗效仍存在争议：方法：对可切除的 pCCA 患者进行 LH 和 RH 比较的非随机队列研究进行了系统回顾和荟萃分析。根据发表年份、地区、病例数和铋分类（BC）≥ III 进行了子分析：共纳入19项研究，涉及3838名患者，其中1779人（46%）接受了LH手术，2059人（54%）接受了RH手术。在对报告危险比（HR）的研究进行的亚组分析中，LH与总生存率（OS）的提高有关（logHR 0.59; p = 0.04）。LH的动脉切除率（14% vs. 1%）、输血率（51% vs. 41%）、手术时间（MD 31.44分钟）和胆汁渗漏率（21% vs. 18%）较高，但肝切除术后肝功能衰竭率（9% vs. 21%）和90天死亡率（8% vs. 16%）较低。西方中心的三年无病生存率上升，而东方中心的三年无病生存率下降：结论：在这项分析中，LH与较高的OS有关，但这是一项要求较高的技术。切除侧的决定应考虑多个因素，包括未来的肝脏残余、肿瘤位置、血管受累情况和手术专长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgical Oncology-Oxford 医学-外科

CiteScore

4.50

自引率

0.00%

发文量

169

审稿时长

38 days

期刊介绍： Surgical Oncology is a peer reviewed journal publishing review articles that contribute to the advancement of knowledge in surgical oncology and related fields of interest. Articles represent a spectrum of current technology in oncology research as well as those concerning clinical trials, surgical technique, methods of investigation and patient evaluation. Surgical Oncology publishes comprehensive Reviews that examine individual topics in considerable detail, in addition to editorials and commentaries which focus on selected papers. The journal also publishes special issues which explore topics of interest to surgical oncologists in great detail - outlining recent advancements and providing readers with the most up to date information.