Forensic application of sandpaper spray ionization mass spectrometry (SPS-MS): Direct analysis of solid pharmaceutical formulations and edible cannabis products

IF 1.5 4区 医学 Q2 MEDICINE, LEGAL Journal of forensic sciences Pub Date : 2024-08-05 DOI:10.1111/1556-4029.15592
Karl Angelo M. Rodrillo BSc, Diego M. Costa MSc, Sarah F. C. Viana BSc, Hasti Shahbazi, Rodinei Augusti PhD, Demian R. Ifa PhD
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Abstract

In this work, we employed a new ambient ionization mass spectrometry technique, sandpaper spray mass spectrometry (SPS-MS), as an efficient tool to analyze pills and tablets of pharmaceutical formulations. The following samples were analyzed: regulators of blood pressure, cholesterol, and diabetes, and drugs for the treatment of erectile dysfunction (ED). Additionally, a hard candy of Cannabis sativa containing Δ9-tetrahydrocannabinol (Δ9-THC) and its related isomer cannabidiol (CBD) was also evaluated. The surfaces of the samples, without any prior treatment, were sanded onto triangular-cut sandpaper, and full MS scans (and MS/MS) were acquired in both positive and negative ionization modes. SPS-MS (and MS/MS) allowed for prompt detection of the active pharmaceutical ingredients (APIs) in each formulation. Other components of the formulations, added as excipients, were also tentatively identified. The results described herein indicate that the SPS-MS technique can be applied to fast screening of pills and tablets being potentially used as an efficient tool to detect counterfeit pharmaceutical and illicit products, a current issue of increasing concern.

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砂纸喷雾电离质谱法(SPS-MS)的法医应用:直接分析固体药物制剂和食用大麻产品。
在这项工作中,我们采用了一种新的环境电离质谱技术--砂纸喷雾质谱(SPS-MS),作为分析药物制剂药丸和药片的有效工具。分析了以下样品:血压、胆固醇和糖尿病调节剂,以及治疗勃起功能障碍(ED)的药物。此外,还对一种含有Δ9-四氢大麻酚(Δ9-THC)及其相关异构体大麻二酚(CBD)的大麻硬糖进行了评估。样品表面未经任何事先处理,用三角切割砂纸打磨后,在正离子和负离子模式下获得完整的 MS 扫描(和 MS/MS)。通过 SPS-MS(和 MS/MS)可迅速检测出每种配方中的活性药物成分 (API)。制剂中作为辅料添加的其他成分也得到了初步鉴定。本文描述的结果表明,SPS-MS 技术可用于快速筛查药丸和药片,有可能成为检测假冒药品和非法产品的有效工具,这是当前日益受到关注的一个问题。
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来源期刊
Journal of forensic sciences
Journal of forensic sciences 医学-医学:法
CiteScore
4.00
自引率
12.50%
发文量
215
审稿时长
2 months
期刊介绍: The Journal of Forensic Sciences (JFS) is the official publication of the American Academy of Forensic Sciences (AAFS). It is devoted to the publication of original investigations, observations, scholarly inquiries and reviews in various branches of the forensic sciences. These include anthropology, criminalistics, digital and multimedia sciences, engineering and applied sciences, pathology/biology, psychiatry and behavioral science, jurisprudence, odontology, questioned documents, and toxicology. Similar submissions dealing with forensic aspects of other sciences and the social sciences are also accepted, as are submissions dealing with scientifically sound emerging science disciplines. The content and/or views expressed in the JFS are not necessarily those of the AAFS, the JFS Editorial Board, the organizations with which authors are affiliated, or the publisher of JFS. All manuscript submissions are double-blind peer-reviewed.
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