Activation of skeletal muscle mechanoreceptors and nociceptors reduces the exercise performance of the contralateral homologous muscles.

IF 2.2 3区 医学 Q3 PHYSIOLOGY American journal of physiology. Regulatory, integrative and comparative physiology Pub Date : 2024-10-01 Epub Date: 2024-08-05 DOI:10.1152/ajpregu.00069.2024
Fabio Zambolin, Fabio Giuseppe Laginestra, Thomas Favaretto, Gaia Giuriato, Matteo Maria Ottaviani, Federico Schena, Pablo Duro-Ocana, Jamie Stewart McPhee, Massimo Venturelli
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Abstract

Increasing evidence suggests that activation of muscle nerve afferents may inhibit central motor drive, affecting contractile performance of remote exercising muscles. Although these effects are well documented for metaboreceptors, very little is known about the activation of mechano- and mechanonociceptive afferents on performance fatigability. Therefore, the purpose of the present study was to examine the influence of mechanoreceptors and nociceptors on performance fatigability. Eight healthy young males undertook four randomized experimental sessions on separate occasions in which the experimental knee extensors were the following: 1) resting (CTRL), 2) passively stretched (ST), 3) resting with delayed onset muscle soreness (DOMS), or 4) passively stretched with DOMS (DOMS+ST), whereas the contralateral leg performed an isometric time to task failure (TTF). Changes in maximal voluntary contraction (ΔMVC), potentiated twitch force (ΔQtw,pot), and voluntary muscle activation (ΔVA) were also assessed. TTF was reduced in DOMS+ST (-43%) and ST (-29%) compared with CTRL. DOMS+ST also showed a greater reduction of VA (-25% vs. -8%, respectively) and MVC compared with CTRL (-28% vs. -45%, respectively). Rate of perceived exertion (RPE) was significantly increased at the initial stages (20-40-60%) of the TTF in DOMS+ST compared with all conditions. These findings indicate that activation of mechanosensitive and mechanonociceptive afferents of a muscle with DOMS reduces TTF of the contralateral homologous exercising limb, in part, by reducing VA, thereby accelerating mechanisms of central fatigue.NEW & NOTEWORTHY We found that activation of mechanosensitive and nociceptive nerve afferents of a rested muscle group experiencing delayed onset muscle soreness was associated with reduced exercise performance of the homologous exercising muscles of the contralateral limb. This occurred with lower muscle voluntary activation of the exercising muscle at the point of task failure.

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激活骨骼肌机械感受器和痛觉感受器会降低对侧同源肌肉的运动表现。
引言:越来越多的证据表明,肌肉神经传入的激活可能会抑制中枢运动驱动力,从而影响远距离运动肌肉的收缩性能。虽然代谢感受器的这些影响已得到充分证实,但对机械和机械痛觉传入激活对运动表现疲劳性的影响却知之甚少。因此,本研究旨在探讨机械感受器和痛觉感受器对运动表现疲劳性的影响:方法:八名健康的年轻男性分别进行了四次随机实验,在实验过程中,实验者的膝关节伸肌分别处于以下状态:a)静止(CTRL);b)被动拉伸(ST);c)静止并伴有 DOMS(DOMS);或 d)被动拉伸并伴有 DOMS(DOMS+ST),同时对侧腿进行等长任务失败时间(TTF)训练。此外,还评估了最大自主收缩力(ΔMVC)、增效抽搐力(ΔQtw,pot)和自主肌肉激活力(ΔVA)的变化:结果:与 CTRL 相比,DOMS+ST(-43%)和 ST(-29%)的 TTF 均有所下降。与 CTRL(分别为 -28% vs -45%)相比,DOMS+ST 的 VA(分别为 -25% vs -8%)和 MVC 下降幅度也更大。与所有条件相比,DOMS+ST 在 TTF 的初始阶段(20%-40%-60%)RPE 明显增加:这些研究结果表明,激活 DOMS 肌肉的机械敏感和机械痛觉传入可降低对侧同源运动肢体的 TTF,部分原因是 VA 减少,从而加速了中枢疲劳机制。
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来源期刊
CiteScore
5.30
自引率
3.60%
发文量
145
审稿时长
2 months
期刊介绍: The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology publishes original investigations that illuminate normal or abnormal regulation and integration of physiological mechanisms at all levels of biological organization, ranging from molecules to humans, including clinical investigations. Major areas of emphasis include regulation in genetically modified animals; model organisms; development and tissue plasticity; neurohumoral control of circulation and hypertension; local control of circulation; cardiac and renal integration; thirst and volume, electrolyte homeostasis; glucose homeostasis and energy balance; appetite and obesity; inflammation and cytokines; integrative physiology of pregnancy-parturition-lactation; and thermoregulation and adaptations to exercise and environmental stress.
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