GP100 expression is variable in intensity in melanoma.

IF 4.6 2区 医学 Q2 IMMUNOLOGY Cancer Immunology, Immunotherapy Pub Date : 2024-08-06 DOI:10.1007/s00262-024-03776-5
Jacqueline E Mann, Nitzan Hasson, David G Su, Adebowale J Adeniran, Keiran S M Smalley, Dijana Djureinovic, Lucia B Jilaveanu, David A Schoenfeld, Harriet M Kluger
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Abstract

Drugs or cellular products that bind to gp100 are being investigated for treatment of cutaneous melanoma. The relative specificity of gp100 expression in melanocytes makes it an attractive target to harness for therapeutic intent. For example, Tebentafusp, a bispecific gp100 peptide-HLA-directed CD3 T cell engager, has generated significant enthusiasm in recent years due to its success in improving outcomes for uveal melanoma and is being studied in cutaneous melanoma. However, the extent and intensity of gp100 expression in advanced cutaneous melanoma has not been well studied. Here, we interrogated a large cohort of primary and metastatic melanomas for gp100 expression by immunohistochemistry. Expression in metastatic samples was globally higher and almost uniformly positive, however the degree of intensity was variable. Using a quantitative immunofluorescence method, we confirmed the variability in expression. As gp100-binding drugs are assessed in clinical trials, the association between activity of the drugs and the level of gp100 expression should be studied in order to potentially improve patient selection.

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黑色素瘤中 GP100 的表达强度不一。
目前正在研究与 gp100 结合的药物或细胞产品,以治疗皮肤黑色素瘤。gp100在黑色素细胞中表达的相对特异性使其成为一个极具吸引力的治疗靶点。例如,Tebentafusp是一种双特异性gp100肽-HLA定向CD3 T细胞吸引剂,近年来由于成功改善了葡萄膜黑色素瘤的治疗效果而引起了极大的反响,目前正在皮肤黑色素瘤领域进行研究。然而,gp100 在晚期皮肤黑色素瘤中的表达范围和强度还没有得到很好的研究。在这里,我们用免疫组化方法检测了一大批原发性和转移性黑色素瘤的gp100表达情况。转移瘤样本中gp100的表达量总体较高,几乎呈均匀的阳性,但强度不一。我们使用定量免疫荧光方法证实了表达的差异性。随着临床试验中对gp100结合药物的评估,应研究药物活性与gp100表达水平之间的关联,以便改进对患者的选择。
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来源期刊
CiteScore
10.50
自引率
1.70%
发文量
207
审稿时长
1 months
期刊介绍: Cancer Immunology, Immunotherapy has the basic aim of keeping readers informed of the latest research results in the fields of oncology and immunology. As knowledge expands, the scope of the journal has broadened to include more of the progress being made in the areas of biology concerned with biological response modifiers. This helps keep readers up to date on the latest advances in our understanding of tumor-host interactions. The journal publishes short editorials including "position papers," general reviews, original articles, and short communications, providing a forum for the most current experimental and clinical advances in tumor immunology.
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