Is there any association between blood glycoalkaloid levels and anencephaly in human?

IF 2.5 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY Clinical biochemistry Pub Date : 2024-08-03 DOI:10.1016/j.clinbiochem.2024.110809

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Abstract

Aim

In various experimental animal studies, it has been proven that solanine, a subtype of glycoalkaloids, is responsible for neural tube defects. However, there have not been any human studies yet in this area. Our aim is to investigate whether there are any connections between blood glycoalkaloid levels and anencephaly in humans.

Methods

Blood and amniotic fluid samples were taken from patients diagnosed with fetal anencephaly during pregnancy. The samples from patients with normal pregnancies were taken as well and was compared to the patients with fetal anencephaly during pregnancy. We searched the levels of three glycoalkaloids: solanine, chaconine and solamargine in the collected samples.

Results

Solanine, which is one of the glycoalkaloids, could not be detected in both serum and amniotic fluid in the anencephaly as well as the control groups. However, alpha-solamargine levels were observed to be significantly higher in the blood and amniotic fluid samples of the control group than in the study group (p = 0.04). Alpha-chaconine levels were also significantly higher in the control group (p < 0.001) as well.

Conclusion

Based on our tests, we can conclude that no connections were found between blood solanine levels and anencephaly during pregnancy. Alpha-chaconine and alpha-solamargine levels were observed to be higher in blood and amniotic fluid in pregnancies without anencephaly. The relationship between glycoalkaloids and congenital anomalies needs to be further investigated in tissues other than blood.

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人类血液中的糖醛酸水平与无脑畸形之间是否存在关联？

目的：在各种动物实验研究中，已证实茄碱（一种糖类生物碱）是导致神经管畸形的原因。然而，目前还没有这方面的人体研究。我们的目的是研究血液中的糖类生物碱水平与人类无脑畸形之间是否存在联系：方法：从妊娠期被诊断为胎儿无脑畸形的患者身上采集血液和羊水样本。我们还从正常妊娠患者身上采集了样本，并与妊娠期胎儿无脑畸形患者进行了比较。我们检测了采集样本中三种糖生物碱的含量：茄碱、查康碱和茄马碱：结果：在无脑畸形组和对照组的血清和羊水中均未检测到作为糖生物碱之一的茄碱。不过，在对照组的血液和羊水样本中，α-茄碱的水平明显高于研究组（p = 0.04）。对照组的α-可可碱水平也明显高于研究组（p 结论：研究组的α-可可碱水平明显高于对照组：根据测试结果，我们可以得出结论，血液中的茄碱水平与孕期无脑畸形之间没有关联。在没有无脑畸形的孕妇中，血液和羊水中的α-查可宁和α-索拉马宁水平较高。糖生物碱与先天性畸形之间的关系需要在血液以外的组织中进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical biochemistry 医学-医学实验技术

CiteScore

5.10

自引率

0.00%

发文量

151

审稿时长

25 days

期刊介绍： Clinical Biochemistry publishes articles relating to clinical chemistry, molecular biology and genetics, therapeutic drug monitoring and toxicology, laboratory immunology and laboratory medicine in general, with the focus on analytical and clinical investigation of laboratory tests in humans used for diagnosis, prognosis, treatment and therapy, and monitoring of disease.