Superiority of opioid free anesthesia with regional block over opioid anesthesia with regional block in the quality of recovery after retroperitoneiscopic renal surgery: a randomized controlled trial.

IF 2.9 3区医学 Q1 ANESTHESIOLOGY Minerva anestesiologica Pub Date : 2024-10-01 Epub Date: 2024-08-06 DOI:10.23736/S0375-9393.24.18186-2

Han Gao, Zhibiao Xu, Li Zhang, Yuyun Liu, Yunru Jiang, Qingfeng Wang, Hongyan Liu, He Liu, Linlin Zhao

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Abstract

Background: Opioids are the main analgesic drugs used in the perioperative period, but they often have various adverse effects. Recent studies have shown that quadratus lumborum block (QLB) has an opioid sparing effect. The aim of this study was to further evaluate the effect of opioid-free anesthesia (OFA) combined with regional block on the quality of recovery in patients undergoing retroperitoneoscopic renal surgery.

Methods: Sixty patients undergoing elective retroperitoneoscopic renal surgery were divided into the opioid-free anesthesia with quadratus lumborum block group (OFA group, N.=30) and opioid anesthesia with quadratus lumborum block group (OA group, N.=30) using the random number table method. The main outcome measures were the quality of recovery assessed by Quality of Recover-40 (QoR-40) at the 24^th postoperative hour. Secondary outcomes were postoperative pain score, postoperative opioid consumption, postoperative nausea and vomiting, time to ambulate, and time to readiness for discharge.

Results: The QoR-40 score on the first postoperative day was significantly higher in the OFA group than that in the OA group (175.41±6.74 vs. 165.07±4.55; P<0.05). OFA also significantly reduced postoperative pain (P<0.05) and morphine consumption at both the 24th and 48th postoperative hour (P<0.05), as well as time to ambulate, and time to readiness for discharge (P<0.05).

Conclusions: OFA with regional block is superior to opioid anesthesia with regional block in the quality of recovery after retroperitoneiscopic renal surgery.

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不含阿片类药物的区域阻滞麻醉在腹膜后肾脏手术后恢复质量方面优于含阿片类药物的区域阻滞麻醉：随机对照试验。

背景：阿片类药物是围手术期的主要镇痛药物，但它们往往会产生各种不良反应。最近的研究表明，腰椎四头肌阻滞（QLB）具有节省阿片类药物的作用。本研究旨在进一步评估无阿片麻醉（OFA）联合区域阻滞对后腹腔镜肾脏手术患者恢复质量的影响：采用随机数字表法将60例择期接受后腹腔镜肾脏手术的患者分为无阿片类麻醉联合腰四肌阻滞组（OFA组，N=30）和阿片类麻醉联合腰四肌阻滞组（OA组，N=30）。主要结果指标是术后第24小时的恢复质量（QoR-40）。次要结果为术后疼痛评分、术后阿片类药物用量、术后恶心呕吐、下地活动时间和准备出院时间：结果：OFA 组术后第一天的 QoR-40 评分明显高于 OA 组（175.41±6.74 vs. 165.07±4.55；PC 结论：OFA 加区域阻滞优于 OA：带区域阻滞的 OFA 在腹膜后肾脏手术后的恢复质量方面优于带区域阻滞的阿片类麻醉。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Minerva anestesiologica 医学-麻醉学

CiteScore

4.50

自引率

21.90%

发文量

367

审稿时长

4-8 weeks

期刊介绍： Minerva Anestesiologica is the journal of the Italian National Society of Anaesthesia, Analgesia, Resuscitation, and Intensive Care. Minerva Anestesiologica publishes scientific papers on Anesthesiology, Intensive care, Analgesia, Perioperative Medicine and related fields. Manuscripts are expected to comply with the instructions to authors which conform to the Uniform Requirements for Manuscripts Submitted to Biomedical Editors by the International Committee of Medical Journal Editors.