Prophylactic and therapeutic cancer vaccine with continuous localized immunomodulation

IF 4.2 2区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Nanomedicine : nanotechnology, biology, and medicine Pub Date : 2024-08-03 DOI:10.1016/j.nano.2024.102776
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Abstract

Selective in vivo immune cell manipulation offers a promising strategy for cancer vaccines. In this context, spatiotemporal control over recruitment of specific cells, and their direct exposure to appropriate immunoadjuvants and antigens are key to effective cancer vaccines. We present an implantable 3D-printed cancer vaccine platform called the ‘NanoLymph’ that enables spatiotemporally-controlled recruitment and manipulation of immune cells in a subcutaneous site. Leveraging two reservoirs each for continuous immunoadjuvant release or antigen presentation, the NanoLymph attracts dendritic cells (DCs) on site and exposes them to tumor-associated antigens. Upon local antigen-specific activation, DCs are mobilized to initiate a systemic immune response. NanoLymph releasing granulocyte-macrophage colony-stimulating factor and CpG-oligodeoxynucleotides with irradiated whole cell tumor lysate inhibited tumor growth of B16F10 murine melanoma in a prophylactic and therapeutic vaccine setting. Overall, this study presents the NanoLymph as a versatile cancer vaccine development platform with replenishable and controlled local release of antigens and immunoadjuvants.

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具有持续局部免疫调节作用的预防性和治疗性癌症疫苗。
选择性体内免疫细胞操作为癌症疫苗提供了一种前景广阔的策略。在这种情况下,对特定细胞招募的时空控制以及它们与适当免疫佐剂和抗原的直接接触是有效癌症疫苗的关键。我们展示了一种名为 "NanoLymph "的植入式三维打印癌症疫苗平台,它能在皮下部位实现时空控制的免疫细胞招募和操纵。NanoLymph 利用两个可持续释放免疫佐剂或呈递抗原的储库,吸引树突状细胞(DC),使其接触肿瘤相关抗原。局部抗原特异性激活后,树突状细胞被动员起来,启动全身免疫反应。释放粒细胞-巨噬细胞集落刺激因子和CpG-寡脱氧核苷酸的纳米淋巴与辐照全细胞肿瘤裂解物一起,在预防和治疗疫苗环境中抑制了B16F10小鼠黑色素瘤的肿瘤生长。总之,这项研究表明,NanoLymph 是一种多功能癌症疫苗开发平台,可在局部补充和控制抗原和免疫佐剂的释放。
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来源期刊
CiteScore
11.10
自引率
0.00%
发文量
133
审稿时长
42 days
期刊介绍: The mission of Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine: NBM) is to promote the emerging interdisciplinary field of nanomedicine. Nanomedicine: NBM is an international, peer-reviewed journal presenting novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the life and health sciences. Content includes basic, translational, and clinical research addressing diagnosis, treatment, monitoring, prediction, and prevention of diseases.
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