Decoding molecular mechanisms: brain aging and Alzheimer's disease.

IF 5.9 2区医学 Q2 CELL BIOLOGY Neural Regeneration Research Pub Date : 2025-08-01 Epub Date: 2024-07-29 DOI:10.4103/NRR.NRR-D-23-01403

Mahnoor Hayat, Rafay Ali Syed, Hammad Qaiser, Mohammad Uzair, Khalid Al-Regaiey, Roaa Khallaf, Lubna Abdullah Mohammed Albassam, Imdad Kaleem, Xueyi Wang, Ran Wang, Mehwish S Bhatti, Shahid Bashir

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Abstract

The complex morphological, anatomical, physiological, and chemical mechanisms within the aging brain have been the hot topic of research for centuries. The aging process alters the brain structure that affects functions and cognitions, but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease. Beyond these observable, mild morphological shifts, significant functional modifications in neurotransmission and neuronal activity critically influence the aging brain. Understanding these changes is important for maintaining cognitive health, especially given the increasing prevalence of age-related conditions that affect cognition. This review aims to explore the age-induced changes in brain plasticity and molecular processes, differentiating normal aging from the pathogenesis of Alzheimer's disease, thereby providing insights into predicting the risk of dementia, particularly Alzheimer's disease.

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解码分子机制：大脑衰老与阿尔茨海默病。

几个世纪以来，大脑衰老过程中复杂的形态、解剖、生理和化学机制一直是研究的热点。衰老过程会改变大脑结构，从而影响大脑功能和认知能力，而这些过程的恶化则是阿尔茨海默病等神经退行性疾病的发病机理之一。除了这些可观察到的轻微形态变化外，神经传导和神经元活动的显著功能变化也对衰老的大脑产生了至关重要的影响。了解这些变化对于保持认知健康非常重要，尤其是考虑到影响认知的老年相关疾病日益普遍。本综述旨在探讨由年龄引起的大脑可塑性和分子过程的变化，将正常衰老与阿尔茨海默病的发病机制区分开来，从而为预测痴呆症（尤其是阿尔茨海默病）的风险提供见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES

CiteScore

8.00

自引率

9.80%

发文量

515

审稿时长

1.0 months

期刊介绍： Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.