Opioids and personalized analgesia in the perioperative setting: A protocol for five systematic reviews.

IF 1.9 4区医学 Q2 ANESTHESIOLOGY Acta Anaesthesiologica Scandinavica Pub Date : 2024-08-06 DOI:10.1111/aas.14508

Anders Peder Højer Karlsen, Pernille Bjersand Sunde, Markus Harboe Olsen, Jens Laigaard, Caroline Folkersen, Trang Xuan Minh Tran, Ida Houtved Rasmussen, Selma Kjartansdóttir, Atena Saito, Michael Asger Andersen, Mathias Maagaard, Nicholas Papadomanolakis-Pakis, Kim Dalhoff, Lone Nikolajsen, Troels Haxholdt Lunn, Christian Sylvest Meyhoff, Janus Christian Jakobsen, Ole Mathiesen

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Abstract

Background: Treatment with opioids is a mainstay in perioperative pain management. While the leading treatment paradigm has been procedure-specific pain management, efforts regarding personalized pain treatment are increasing. The OPI•AID project aims to develop personalized algorithms for perioperative pain management, taking demographic, surgical, and anaesthesiologic factors into account. We will undertake five parallel reviews to illuminate current evidence on different aspects of individual responses to perioperative opioid treatment.

Methods: Inclusion of adult populations in English-written studies. Review-specific searches are developed for the following databases: CENTRAL, MEDLINE, Embase, clinicaltrials.gov, and clinicaltrial.eu. Two authors will independently screen citations, extract data, and assess the risks of bias in each review (QUIPS, PROBAST and RoB2, as relevant).

Conclusion: These reviews will evaluate various aspects of perioperative opioid treatment, including individualized treatment strategies, selection of specific opioids, and individual patient responses. These will guide future development of a personalized perioperative opioid treatment algorithm (OPI•AID) that will be validated and tested clinically against standard of care.

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围术期阿片类药物和个性化镇痛：五项系统性综述方案。

背景：阿片类药物治疗是围手术期疼痛治疗的主要方法。虽然针对特定手术的疼痛治疗一直是主要的治疗模式，但有关个性化疼痛治疗的努力正在不断增加。OPI-AID 项目旨在开发围术期疼痛治疗的个性化算法，将人口统计学、手术和麻醉学因素考虑在内。我们将同时进行五项综述，以阐明目前关于围术期阿片类药物治疗个体反应不同方面的证据：纳入英文研究中的成人群体。对以下数据库进行特定综述检索：CENTRAL、MEDLINE、Embase、clinicaltrials.gov 和 clinicaltrial.eu。两位作者将独立筛选引文、提取数据并评估每篇综述（QUIPS、PROBAST 和 RoB2，如相关）的偏倚风险：这些综述将评估围手术期阿片类药物治疗的各个方面，包括个体化治疗策略、特定阿片类药物的选择以及患者的个体反应。这些内容将指导未来围手术期阿片类药物个性化治疗算法（OPI-AID）的开发，该算法将根据标准护理进行临床验证和测试。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Anaesthesiologica Scandinavica 医学-麻醉学

CiteScore

4.30

自引率

9.50%

发文量

157

审稿时长

3-8 weeks

期刊介绍： Acta Anaesthesiologica Scandinavica publishes papers on original work in the fields of anaesthesiology, intensive care, pain, emergency medicine, and subjects related to their basic sciences, on condition that they are contributed exclusively to this Journal. Case reports and short communications may be considered for publication if of particular interest; also letters to the Editor, especially if related to already published material. The editorial board is free to discuss the publication of reviews on current topics, the choice of which, however, is the prerogative of the board. Every effort will be made by the Editors and selected experts to expedite a critical review of manuscripts in order to ensure rapid publication of papers of a high scientific standard.