Comparative Efficacy of Aristolochia rotunda L. (Zarawand Mudaharaj) and Saussurea lappa C.B. Clarke (Qust) in Primary Dysmenorrhea--A Single-Blind Randomized Clinical Study.

IF 1.9 4区医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE Alternative therapies in health and medicine Pub Date : 2024-08-01

Syeda Sumaiya, Wajeeha Begum, Shabnam Bano, Nazim Husain

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Abstract

Background: The use of plant medications in Unani medicine has been suggested to alleviate pain and related symptoms associated with primary dysmenorrhea, thus enhancing the overall quality of life. The purpose of the current study was to evaluate and compare the efficacy of Zarawand Mudaharaj (Aristolochia rotunda L.) and Qust (Saussurea lappa C.B. Clarke) in treating primary dysmenorrhea.

Methods: This single-blind, randomized comparative study was conducted on patients with primary dysmenorrhea aged 18-35 years. The study participants were randomly allocated into Group A and Group B. Group A received Zarawand Mudaharaj 2 g twice daily with 5 mL honey while Group B received Qust 1.5 g twice daily with 5 mL honey from the 1st to the 5th day of their menstrual cycles for three consecutive cycles. The primary outcome measures were changes in pain severity measured on a 10 cm Visual Analog Scale (VAS) and changes in Verbal Multidimensional Scoring System (VMSS) grades. The secondary outcome measures included changes in Health-Related Quality of Life (HRQoL) measured on short form health survey-12 (SF-12) and changes in the symptoms such as pain during menstruation, low-backache, nausea, vomiting, diarrhoea, giddiness, and headache.

Results: Both groups showed a significant improvement in VMSS grade at all follow-ups compared to baseline (P < .0001). Group B showed better performance than Group A in changing the VMSS grade at the third cycle (P = .02) and the final follow-up (P = .002). Group B also had a more significant reduction in mean ± SD VAS score from baseline (6.43 ± 1.57) to the final follow-up (2.67 ± 1.69) (P < .0001) compared to Group A.

Conclusion: The preliminary findings of the study support the use of Zarawand Mudaharaj and Qust in the treatment of primary dysmenorrhea, which is consistent with the traditional knowledge of Unani scholars.

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马兜铃（Zarawand Mudaharaj）和瞿麦（Saussurea lappa C.B. Clarke）对原发性痛经的疗效比较--一项单盲随机临床研究。

背景：尤那尼医学中的植物药物被认为可以减轻原发性痛经引起的疼痛和相关症状，从而提高整体生活质量。本研究旨在评估和比较 Zarawand Mudaharaj（马兜铃科植物）和 Qust（Saussurea lappa C.B. Clarke）治疗原发性痛经的疗效：这项单盲随机比较研究的对象是 18-35 岁的原发性痛经患者。A 组服用 Zarawand Mudaharaj 2 克，每日两次，加 5 毫升蜂蜜；B 组服用 Qust 1.5 克，每日两次，加 5 毫升蜂蜜，从月经周期的第 1 天到第 5 天，连续服用三个周期。主要结果指标是以 10 厘米视觉模拟量表（VAS）测量的疼痛严重程度的变化和口头多维评分系统（VMSS）等级的变化。次要结果指标包括以简表健康调查-12（SF-12）衡量的与健康相关的生活质量（HRQoL）的变化，以及月经期间疼痛、腰痛、恶心、呕吐、腹泻、眩晕和头痛等症状的变化：与基线相比，两组在所有随访中的 VMSS 分级均有明显改善（P < .0001）。在第三个周期（P = .02）和最终随访（P = .002）的 VMSS 分级变化方面，B 组的表现优于 A 组。与 A 组相比，B 组从基线（6.43 ± 1.57）到最终随访（2.67 ± 1.69）的平均 ± SD VAS 评分也有更显著的下降（P < .0001）：研究的初步结果支持使用 Zarawand Mudaharaj 和 Qust 治疗原发性痛经，这与尤那尼学者的传统知识是一致的。

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Alternative therapies in health and medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

0.90

自引率

0.00%

发文量

219

期刊介绍： Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat disease. Alternative Therapies in Health and Medicine was the first journal in this field to be indexed in the National Library of Medicine. In 2006, 2007, and 2008, ATHM had the highest impact factor ranking of any independently published peer-reviewed CAM journal in the United States—meaning that its research articles were cited more frequently than any other journal’s in the field. Alternative Therapies in Health and Medicine does not endorse any particular system or method but promotes the evaluation and appropriate use of all effective therapeutic approaches. Each issue contains a variety of disciplined inquiry methods, from case reports to original scientific research to systematic reviews. The editors encourage the integration of evidence-based emerging therapies with conventional medical practices by licensed health care providers in a way that promotes a comprehensive approach to health care that is focused on wellness, prevention, and healing. Alternative Therapies in Health and Medicine hopes to inform all licensed health care practitioners about developments in fields other than their own and to foster an ongoing debate about the scientific, clinical, historical, legal, political, and cultural issues that affect all of health care.