Development of a Simple Analytical Model to Facilitate Preoperative Surgical Planning in Valve-Sparing Aortic Root Replacement.

IF 3 2区 医学 Q3 ENGINEERING, BIOMEDICAL Annals of Biomedical Engineering Pub Date : 2024-08-06 DOI:10.1007/s10439-024-03593-y
Dominic P Recco, Shannen B Kizilski, Wen Zhang, Nicholas E Kneier, Patrick D Earley, David M Hoganson, Christopher W Baird, Peter E Hammer
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Abstract

Purpose: Valve-sparing root replacement (VSRR) is attractive for aortic root dilation as it preserves the native aortic valve (AoV). Low effective height (eH) after reconstruction is a risk factor for repair failure and reoperation. We developed and validated a quantitative AoV repair strategy to reliably restore normal valve proportions to promote long-term function.

Methods: Normal AoV proportions were used to derive geometric relationships for sinotubular junction diameter (DSTJ), free edge length (FEL), free edge angle, and commissure height. These relationships informed two models for predicting eH following VSRR: (1) assuming valve symmetry and (2) accounting for valve asymmetry. Porcine heart (n = 6) ex vivo validation was performed under 4 VSRR scenarios: "Ideal" (tube graft size targeting FEL/DSTJ = 1.28), "Oversized" (one graft size larger than Ideal), "Undersized" (two sizes smaller), and "Undersized + Plicated" (FEL/DSTJ = 1.28 restored with leaflet plication).

Results: Our analytical models predicted eH using preoperative measurements and estimated reconstructed dimensions. The Oversized graft exhibited similar eH to Ideal but higher regurgitation in the ex vivo model, whereas the Undersized graft demonstrated lower eH and regurgitation. Plication in the Undersized graft restored valve function (regurgitation & eH) similar to Ideal in the ex vivo model and above Ideal in the analytical models. Both analytical models predicted ex vivo eH well except in the Oversized and Undersized + Plicated conditions.

Conclusion: Utilizing measurements from preoperative imaging and simple mathematical models, patient-specific operative plans for VSRR can be created by estimating valve dimensions necessary to achieve favorable valve features post-repair. Clinical application of this approach promises to improve consistency in achieving optimal long-term dimensions and durability.

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开发简易分析模型,为主动脉根部瓣膜置换术的术前手术规划提供便利。
目的:保瓣主动脉根部置换术(VSRR)可保留原生主动脉瓣(AoV),对主动脉根部扩张具有吸引力。重建后的低有效高度(eH)是导致修复失败和再次手术的风险因素。我们开发并验证了一种定量主动脉瓣修复策略,以可靠地恢复正常瓣膜比例,促进长期功能:方法:正常瓣膜比例用于推导窦管交界处直径(DSTJ)、游离缘长度(FEL)、游离缘角度和合谷高度的几何关系。这些关系为预测 VSRR 后 eH 的两个模型提供了依据:(1) 假设瓣膜对称;(2) 考虑瓣膜不对称。在 4 种 VSRR 情景下对猪心(n = 6)进行了体外验证:"理想"(以 FEL/DSTJ = 1.28 为目标的移植管尺寸)、"过大"(比理想尺寸大一个移植管尺寸)、"过小"(比理想尺寸小两个移植管尺寸)和 "过小 + 植入"(FEL/DSTJ = 1.28 修复并植入瓣叶):我们的分析模型利用术前测量值和估计的重建尺寸预测了 eH。在体外模型中,过大移植物的eH值与理想值相似,但反流率较高,而过小移植物的eH值和反流率较低。在体外模型中,小尺寸移植物的复制恢复了与理想瓣膜相似的瓣膜功能(反流和 eH),而在分析模型中则高于理想值。两个分析模型都能很好地预测体内eH,但过大和过小+复制条件除外:结论:利用术前成像的测量结果和简单的数学模型,通过估算瓣膜修复后获得良好瓣膜功能所需的瓣膜尺寸,可以制定针对患者的 VSRR 手术计划。这种方法的临床应用有望提高实现最佳长期尺寸和耐用性的一致性。
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来源期刊
Annals of Biomedical Engineering
Annals of Biomedical Engineering 工程技术-工程:生物医学
CiteScore
7.50
自引率
15.80%
发文量
212
审稿时长
3 months
期刊介绍: Annals of Biomedical Engineering is an official journal of the Biomedical Engineering Society, publishing original articles in the major fields of bioengineering and biomedical engineering. The Annals is an interdisciplinary and international journal with the aim to highlight integrated approaches to the solutions of biological and biomedical problems.
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