{"title":"Exosomal CircRNAs: A Future Star in Colorectal Cancer.","authors":"Yuanzhi Zhou, Chengyan Wei, Yuqi Xu, Jingjing Wang, Chunwei Zhang, Yong Jin","doi":"10.2174/0115680096323472240710101854","DOIUrl":null,"url":null,"abstract":"<p><p>Colorectal cancer (CRC) is currently the third most common malignancy worldwide, with an increasing mortality rate and treatment resistance. Due to the lack of effective biomarkers and therapeutic targets, the early diagnosis and treatment of colorectal cancer remain suboptimal. Circular RNAs (circRNAs) are a novel class of non-coding RNAs with covalent closed-loop structures that are well stabilized and conserved and are involved in multiple pathological conditions in humans. CircRNAs have been identified to be enriched and stable in exosomes. In addition, there is growing proof that exosomal circRNAs that have been identified as oncogenes or tumor suppressors regulate CRC growth, migration, and sensitivity to radiotherapy and chemotherapy. Exosomal circRNAs represent promising candidates as diagnostic biomarkers and anti-tumor targets. In this article, we explore recent studies on exosomal circRNAs in CRC and describe their biological functions in colorectal cancer development, illustrating their potential as biomarkers and targeted therapeutic capabilities.</p>","PeriodicalId":10816,"journal":{"name":"Current cancer drug targets","volume":" ","pages":"968-983"},"PeriodicalIF":3.5000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current cancer drug targets","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115680096323472240710101854","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Colorectal cancer (CRC) is currently the third most common malignancy worldwide, with an increasing mortality rate and treatment resistance. Due to the lack of effective biomarkers and therapeutic targets, the early diagnosis and treatment of colorectal cancer remain suboptimal. Circular RNAs (circRNAs) are a novel class of non-coding RNAs with covalent closed-loop structures that are well stabilized and conserved and are involved in multiple pathological conditions in humans. CircRNAs have been identified to be enriched and stable in exosomes. In addition, there is growing proof that exosomal circRNAs that have been identified as oncogenes or tumor suppressors regulate CRC growth, migration, and sensitivity to radiotherapy and chemotherapy. Exosomal circRNAs represent promising candidates as diagnostic biomarkers and anti-tumor targets. In this article, we explore recent studies on exosomal circRNAs in CRC and describe their biological functions in colorectal cancer development, illustrating their potential as biomarkers and targeted therapeutic capabilities.
期刊介绍：
Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes.
Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer.
As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.
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