Real-world smartphone data can trace the behavioural impact of epilepsy: A case study

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY European Journal of Neurology Pub Date : 2024-08-07 DOI:10.1111/ene.16433

Arthur R. van Nieuw Amerongen, Anne Marthe Meppelink, Arko Ghosh, Roland D. Thijs

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Abstract

Background

Neurobehavioural comorbidities have a detrimental effect on the quality of life of people with epilepsy, yet tracking their impact is challenging as behaviour may vary with seizures and anti-seizure medication (ASM) side effects. Smartphones have the potential to monitor day-to-day neurobehavioural patterns objectively. We present the case of a man in his late twenties with drug-resistant focal epilepsy in whom we ascertained the effects of ASM withdrawal and a convulsive seizure on his touchscreen interactions.

Methods

Using a dedicated app, we recorded over 185 days the timestamps of 718,357 interactions. We divided the various smartphone behaviours according to the next-interval dynamics of the interactions by using a joint interval distribution (JID). During two ASM load transitions, namely before versus during tapering and tapering versus restarting medication, we used cluster-based permutation tests to compare the JIDs. We also compared the JID of the seizure day to the average of the previous 3 days.

Results

The cluster-based permutation tests revealed significant differences, with accelerated next-interval dynamics during tapering and a reversal upon medication restart. The day of the convulsion exhibited a marked slowing of next-interval dynamics compared to the preceding 3 days.

Conclusion

Our findings suggest that the temporal dynamics of smartphone touchscreen interactions may help monitor neurobehavioural comorbidities in neurological care.

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真实世界的智能手机数据可追踪癫痫对行为的影响：案例研究。

背景：神经行为合并症对癫痫患者的生活质量有不利影响，但追踪其影响却很困难，因为行为可能会随着癫痫发作和抗癫痫药物（ASM）副作用的变化而变化。智能手机具有客观监测日常神经行为模式的潜力。我们介绍了一名二十多岁患有耐药性局灶性癫痫的男子的病例，我们确定了抗癫痫药物停药和抽搐发作对其触摸屏互动的影响：我们使用专用应用程序记录了 185 天内 718,357 次交互的时间戳。我们使用联合时间间隔分布（JID），根据交互的下一时间间隔动态来划分各种智能手机行为。在两个 ASM 负载转换期间，即减量前与减量期间、减量与重新开始用药期间，我们使用基于聚类的置换检验来比较 JID。我们还将癫痫发作日的 JID 与前 3 天的平均值进行了比较：结果：基于聚类的置换检验显示了显著的差异，在减药期间，下一时间段的动态变化加快，而在重新开始用药后，情况发生了逆转。与前 3 天相比，抽搐当天的下一时间动态明显减慢：我们的研究结果表明，智能手机触摸屏互动的时间动态可能有助于监测神经科护理中的神经行为合并症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Neurology 医学-临床神经学

CiteScore

9.70

自引率

2.00%

发文量

418

审稿时长

1 months

期刊介绍： The European Journal of Neurology is the official journal of the European Academy of Neurology and covers all areas of clinical and basic research in neurology, including pre-clinical research of immediate translational value for new potential treatments. Emphasis is placed on major diseases of large clinical and socio-economic importance (dementia, stroke, epilepsy, headache, multiple sclerosis, movement disorders, and infectious diseases).