The effect of central sleep apnea on sleep architecture in children with obstructive sleep apnea

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-08-01 DOI:10.1016/j.ijporl.2024.112053

ChenXi Luo , WenBo Chen , Qi Li

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Abstract

Objective

This study aimed to investigate how central sleep apnea (CSA) impacts sleep patterns in children with obstructive sleep apnea (OSA).

Methods

Children undergoing polysomnography (PSG) were enrolled and sorted into two groups: those with OSA alone (Group A) and those with both OSA and CSA (CAI <1 nd: children with 10 % CSA or more and less than 50 %, Group B). Statistical analysis was conducted to compare sleep structure and clinical features between Group A and Group B.

Results

Group B exhibited significantly higher respiratory events, apnea hypoventilation index, apnea index and oxygen desaturation index (ODI) compared to Group A (p < 0.05). Group B also showed higher total sleep time and arousal index than Group A (P < 0.05). The proportion of time spent in stage N3 was lower in Group B than in Group A (P < 0.05). Moreover, mean heart rate and minimum heart rate were higher in Group B compared to Group A (P < 0.05).Minimum oxygenation levels (including non-rapid eye movement (NREM) stages) were lowe in Group B than in Group A (P < 0.05). Additionally, the prevalence of positional obstructive sleep apnea (P-OSA) was greater in Group B than in Group A (P < 0.05).

Conclusion

In comparison to those with OSA alone, children with OSA and concurrent CSA exhibited distinct sleep patterns, including reduced N3uration, higher arousal index, longer respiratory events, higher ODI, and lower oxygen saturation, higher heart rate.

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中枢性睡眠呼吸暂停对阻塞性睡眠呼吸暂停儿童睡眠结构的影响。

研究目的本研究旨在探讨中枢性睡眠呼吸暂停（CSA）如何影响患有阻塞性睡眠呼吸暂停（OSA）的儿童的睡眠模式：方法：将接受多导睡眠图（PSG）检查的儿童分为两组：仅患有 OSA 的儿童（A 组）和同时患有 OSA 和 CSA 的儿童（CAI 结果）：与 A 组相比，B 组的呼吸事件、呼吸暂停低通气指数、呼吸暂停指数和血氧饱和度指数（ODI）明显更高（p 结论：与单纯 OSA 患儿相比，CAI 患儿的呼吸事件、呼吸暂停低通气指数、呼吸暂停指数和血氧饱和度指数（ODI）明显更高：与单纯患有 OSA 的儿童相比，患有 OSA 并同时伴有 CSA 的儿童表现出不同的睡眠模式，包括 N3uration 降低、唤醒指数升高、呼吸时间延长、ODI 升高、血氧饱和度降低、心率升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.