{"title":"Contributions of T Cell Signaling for Wound Healing.","authors":"Lingzhang Meng, Qiang Tang, Wei Zhou, Dalong Wei, Jingjie Zhao, Jiajia Shen, Mingyue Yang, Siyuan He, Shaoang Huang, Yujuan Qin, Jian Song, Liangping Luo, Qianli Tang","doi":"10.1093/jbcr/irae151","DOIUrl":null,"url":null,"abstract":"<p><p>It has long been known that T cells participate in wound healing; however, the landscape of the signaling derived from T cells in the process of wound healing is still enigmatic. With the advantages of scRNA-seq, in combination with immunofluorescent imaging, we identified activated T cells, cytotoxic T cells (CTLs), exhausting T cells, and Tregs existing in the inflammation phase of wound healing. Further analysis revealed each T cell population possess distinguished signals contributed to wound healing, some are critical for improving the wound healing quality. Besides, this study discovered and validated the existence of exhausting T cells among the T cells accumulated in the skin during wound healing, and the molecular mechanism(s) and contribution of exhausting T cells to wound healing deserve extensive studies in the future.</p>","PeriodicalId":15205,"journal":{"name":"Journal of Burn Care & Research","volume":" ","pages":"1513-1519"},"PeriodicalIF":1.5000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Burn Care & Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/jbcr/irae151","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CRITICAL CARE MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
It has long been known that T cells participate in wound healing; however, the landscape of the signaling derived from T cells in the process of wound healing is still enigmatic. With the advantages of scRNA-seq, in combination with immunofluorescent imaging, we identified activated T cells, cytotoxic T cells (CTLs), exhausting T cells, and Tregs existing in the inflammation phase of wound healing. Further analysis revealed each T cell population possess distinguished signals contributed to wound healing, some are critical for improving the wound healing quality. Besides, this study discovered and validated the existence of exhausting T cells among the T cells accumulated in the skin during wound healing, and the molecular mechanism(s) and contribution of exhausting T cells to wound healing deserve extensive studies in the future.
人们早就知道 T 细胞参与伤口愈合，然而，T 细胞在伤口愈合过程中的信号转导情况仍然是个谜。利用 scRNA-seq 的优势，结合免疫荧光成像，我们确定了伤口愈合炎症阶段存在的活化 T 细胞、细胞毒性 T 细胞（CTL）、衰竭 T 细胞和 Tregs。进一步的分析表明，每个 T 细胞群对伤口愈合都有不同的信号，其中一些对提高伤口愈合质量至关重要。此外，这项研究还发现并验证了在伤口愈合过程中积聚在皮肤中的 T 细胞中衰竭 T 细胞的存在，而衰竭 T 细胞对伤口愈合的分子机制和贡献值得在未来进行广泛的研究。
期刊介绍：
Journal of Burn Care & Research provides the latest information on advances in burn prevention, research, education, delivery of acute care, and research to all members of the burn care team. As the official publication of the American Burn Association, this is the only U.S. journal devoted exclusively to the treatment and research of patients with burns. Original, peer-reviewed articles present the latest information on surgical procedures, acute care, reconstruction, burn prevention, and research and education. Other topics include physical therapy/occupational therapy, nutrition, current events in the evolving healthcare debate, and reports on the newest computer software for diagnostics and treatment. The Journal serves all burn care specialists, from physicians, nurses, and physical and occupational therapists to psychologists, counselors, and researchers.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
