Effect of patient characteristics on aortic attenuation in iodinated contrast-enhanced Abdominopelvic CT: A retrospective study

Abstract

Introduction

Contrast Enhanced Computed Tomography (CECT) abdomen and pelvis is a common imaging procedure. Hospitals typically follow fixed protocols of contrast volume administration for triple-phase CECT abdomen and pelvis scans and have found that patients are either underdosed or overdosed with respect to their body habitus. The aim of the study was to correlate different patient characteristics such as Total body weight (TBW), Lean Body Mass (LBM), Body Mass Index (BMI), Body Surface Area (BSA) and Blood Volume (BV) with aortic enhancement in the arterial and portal venous phases for CECT Abdomen and pelvis.

Methods

A total of 106 patients who underwent triple-phase CECT abdomen & pelvis were retrospectively studied. A circular region-of-interest (ROI) of 100 mm² was positioned on descending aorta for unenhanced, arterial, and portal venous phases to measure the aortic enhancement in Hounsfield's units. Measure of contrast attenuation (ΔH) was calculated from the difference of CT values on unenhanced images and contrast images. Correlation analysis was performed to evaluate the relation of patient body characteristics with aortic enhancement.

Results

Correlation analysis revealed that BMI exhibited the least correlation when compared to the other characteristics in both arterial (r = −0.3; p = 0.002) and portovenous phases (r = −0.35; p < 0.001) whereas TBW, LBW, BSA and BV reported moderate inverse correlations. BV was found to be the strongest of all characteristics under linear regression.

Conclusion

The study supports the use of protocols that adjust contrast volume to either TBW, LBW, BSA, or BV for CT abdomen and pelvis scan.

Implication of practice

The right body parameter ensures optimal contrast enhancement, improving the visualization of anatomical structures and helps in adapting tailored contrast injection protocols.