Enteroendocrine cells regulate intestinal homeostasis and epithelial function

IF 3.8 3区 医学 Q2 CELL BIOLOGY Molecular and Cellular Endocrinology Pub Date : 2024-08-05 DOI:10.1016/j.mce.2024.112339
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Abstract

Enteroendocrine cells (EECs) are well-known for their systemic hormonal effects, especially in the regulation of appetite and glycemia. Much less is known about how the products made by EECs regulate their local environment within the intestine. Here, we focus on paracrine interactions between EECs and other intestinal cells as they regulate three essential aspects of intestinal homeostasis and physiology: 1) intestinal stem cell function and proliferation; 2) nutrient absorption; and 3) mucosal barrier function. We also discuss the ability of EECs to express multiple hormones, describe in vitro and in vivo models to study EECs, and consider how EECs are altered in GI disease.

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肠内分泌细胞调节肠道稳态和上皮功能
众所周知,肠内分泌细胞(EECs)具有全身性荷尔蒙效应,尤其是在调节食欲和血糖方面。人们对肠内分泌细胞制造的产品如何调节肠道内的局部环境知之甚少。在此,我们将重点研究EECs和其他肠道细胞之间的旁分泌相互作用,因为它们调节肠道平衡和生理的三个重要方面:1)肠道干细胞功能和增殖;2)营养吸收;3)粘膜屏障功能。我们还讨论了 EECs 表达多种激素的能力,描述了研究 EECs 的体外和体内模型,并探讨了肠道疾病如何改变 EECs。
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来源期刊
Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology 医学-内分泌学与代谢
CiteScore
9.00
自引率
2.40%
发文量
174
审稿时长
42 days
期刊介绍: Molecular and Cellular Endocrinology was established in 1974 to meet the demand for integrated publication on all aspects related to the genetic and biochemical effects, synthesis and secretions of extracellular signals (hormones, neurotransmitters, etc.) and to the understanding of cellular regulatory mechanisms involved in hormonal control.
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