Ferroptosis in Cognitive Impairment Associated with Diabetes and Alzheimer's Disease: Mechanistic Insights and New Therapeutic Opportunities.

IF 4.6 2区医学 Q1 NEUROSCIENCES Molecular Neurobiology Pub Date : 2025-02-01 Epub Date: 2024-08-07 DOI:10.1007/s12035-024-04417-9

Mei Ma, Guangchan Jing, Yue Tian, Ruiying Yin, Mengren Zhang

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Abstract

Cognitive impairment associated with diabetes and Alzheimer's disease has become a major health issue affecting older individuals, with morbidity rates growing acutely each year. Ferroptosis is a novel form of cell death that is triggered by iron-dependent lipid peroxidation. A growing body of evidence suggests a strong correlation between the progression of cognitive impairment and diabetes, Alzheimer's disease, and ferroptosis. The pharmacological modulation of ferroptosis could be a promising therapeutic intervention for cognitive impairment associated with diabetes and Alzheimer's disease. In this review, we summarize evidence on ferroptosis in the context of cognitive impairment associated with diabetes and Alzheimer's disease and provide detailed insights into the function and potential action pathways of ferroptosis. Furthermore, we discuss the therapeutic importance of natural ferroptosis products in improving the cognitive impairment associated with diabetes and Alzheimer's disease and provide new insights for clinical treatment.

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与糖尿病和阿尔茨海默病相关的认知障碍中的铁蛋白沉积：机理认识与新的治疗机会》。

与糖尿病和阿尔茨海默病相关的认知障碍已成为影响老年人健康的主要问题，发病率逐年急剧上升。铁过氧化是一种新型的细胞死亡形式，由依赖铁的脂质过氧化引发。越来越多的证据表明，认知障碍的进展与糖尿病、阿尔茨海默病和铁氧化之间存在密切联系。对铁氧化的药理调节可能是治疗糖尿病和阿尔茨海默病相关认知障碍的一种有前景的干预措施。在这篇综述中，我们总结了与糖尿病和阿尔茨海默病相关的认知障碍中有关铁蛋白沉积的证据，并详细介绍了铁蛋白沉积的功能和潜在作用途径。此外，我们还讨论了天然铁蛋白产品在改善糖尿病和阿尔茨海默病相关认知障碍方面的治疗重要性，并为临床治疗提供了新的见解。

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来源期刊

Molecular Neurobiology 医学-神经科学

CiteScore

9.00

自引率

2.00%

发文量

480

审稿时长

1 months

期刊介绍： Molecular Neurobiology is an exciting journal for neuroscientists needing to stay in close touch with progress at the forefront of molecular brain research today. It is an especially important periodical for graduate students and "postdocs," specifically designed to synthesize and critically assess research trends for all neuroscientists hoping to stay active at the cutting edge of this dramatically developing area. This journal has proven to be crucial in departmental libraries, serving as essential reading for every committed neuroscientist who is striving to keep abreast of all rapid developments in a forefront field. Most recent significant advances in experimental and clinical neuroscience have been occurring at the molecular level. Until now, there has been no journal devoted to looking closely at this fragmented literature in a critical, coherent fashion. Each submission is thoroughly analyzed by scientists and clinicians internationally renowned for their special competence in the areas treated.