Rapid Eye Movements during REM Sleep Differentiate PSP from Parkinson's Disease.

IF 2.6 4区医学 Q2 CLINICAL NEUROLOGY Movement Disorders Clinical Practice Pub Date : 2024-10-01 Epub Date: 2024-08-07 DOI:10.1002/mdc3.14187

Claudio Togni, Sandra Carpinelli, Philipp O Valko, Christopher Bockisch, Daniel Waldvogel, Esther Werth, Konrad P Weber, Yulia Valko

{"title":"Rapid Eye Movements during REM Sleep Differentiate PSP from Parkinson's Disease.","authors":"Claudio Togni, Sandra Carpinelli, Philipp O Valko, Christopher Bockisch, Daniel Waldvogel, Esther Werth, Konrad P Weber, Yulia Valko","doi":"10.1002/mdc3.14187","DOIUrl":null,"url":null,"abstract":"Background: Little is known about the characteristics and occurrence frequencies of rapid eye movements (REMs) during REM sleep in movement disorders.Objectives: The aim of this study was to detect and characterize REMs during polysomnographically defined REM sleep as recorded by electro-oculography (EOG) in 12 patients with progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD) and 12 healthy controls.Methods: Using a modified EOG montage, we developed an algorithm that automatically detects and characterizes REMs during REM sleep based on their presumptive saccadic kinematics.Results: Compared to PD and healthy controls, REM densities and REM peak velocities were significantly reduced in PSP. These effects were most pronounced in vertical REMs.Conclusion: Ocular motor dysfunction, one of the cardinal features of PSP, seems to be equally at play during REM sleep and wakefulness. For future studies, we provide a novel tool for the unbiased analysis of REMs during REM sleep in movement disorders.","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":"1281-1285"},"PeriodicalIF":2.6000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11489613/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Movement Disorders Clinical Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/mdc3.14187","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/7 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Little is known about the characteristics and occurrence frequencies of rapid eye movements (REMs) during REM sleep in movement disorders.

Objectives: The aim of this study was to detect and characterize REMs during polysomnographically defined REM sleep as recorded by electro-oculography (EOG) in 12 patients with progressive supranuclear palsy (PSP), 13 patients with Parkinson's disease (PD) and 12 healthy controls.

Methods: Using a modified EOG montage, we developed an algorithm that automatically detects and characterizes REMs during REM sleep based on their presumptive saccadic kinematics.

Results: Compared to PD and healthy controls, REM densities and REM peak velocities were significantly reduced in PSP. These effects were most pronounced in vertical REMs.

Conclusion: Ocular motor dysfunction, one of the cardinal features of PSP, seems to be equally at play during REM sleep and wakefulness. For future studies, we provide a novel tool for the unbiased analysis of REMs during REM sleep in movement disorders.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

快速眼动睡眠期间的快速眼动可区分帕金森病和帕金森综合症

背景：人们对运动障碍患者快速眼动睡眠期间快速眼动（REM）的特征和发生频率知之甚少：本研究的目的是检测12名进行性核上性麻痹（PSP）患者、13名帕金森病（PD）患者和12名健康对照者在多导睡眠图定义的快速眼动睡眠中的快速眼动，并描述其特征：方法：我们使用改良的 EOG 蒙太奇，开发了一种算法，可根据推测的眼球运动学自动检测和描述快速动眼期睡眠中的快速动眼期：与帕金森病和健康对照组相比，帕金森病患者的快速动眼期密度和快速动眼期峰值速度明显降低。这些影响在垂直快速动眼期最为明显：结论：眼部运动功能障碍是帕金森病的主要特征之一，在快速眼动睡眠和清醒时似乎同样起作用。对于未来的研究，我们提供了一种新的工具，用于对运动障碍患者快速动眼期睡眠进行无偏见的分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Movement Disorders Clinical Practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

7.50%

发文量

218

期刊介绍： Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)