Multifunctional hydrogel-based engineered extracellular vesicles delivery for complicated wound healing.

IF 12.4 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Theranostics Pub Date : 2024-07-08 eCollection Date: 2024-01-01 DOI:10.7150/thno.97317

Zuhao Li, Jinlong Liu, Jian Song, Zhifeng Yin, Fengjin Zhou, Hao Shen, Guangchao Wang, Jiacan Su

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Abstract

The utilization of extracellular vesicles (EVs) in wound healing has been well-documented. However, the direct administration of free EVs via subcutaneous injection at wound sites may result in the rapid dissipation of bioactive components and diminished therapeutic efficacy. Functionalized hydrogels provide effective protection, as well as ensure the sustained release and bioactivity of EVs during the wound healing process, making them an ideal candidate material for delivering EVs. In this review, we introduce the mechanisms by which EVs accelerate wound healing, and then elaborate on the construction strategies for engineered EVs. Subsequently, we discuss the synthesis strategies and application of hydrogels as delivery systems for the sustained release of EVs to enhance complicated wound healing. Furthermore, in the face of complicated wounds, functionalized hydrogels with specific wound microenvironment regulation capabilities, such as antimicrobial, anti-inflammatory, and immune regulation, used for loading engineered EVs, provide potential approaches to addressing these healing challenges. Ultimately, we deliberate on potential future trajectories and outlooks, offering a fresh viewpoint on the advancement of artificial intelligence (AI)-energized materials and 3D bio-printed multifunctional hydrogel-based engineered EVs delivery dressings for biomedical applications.

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基于水凝胶的多功能细胞外小泡工程输送技术，用于复杂伤口的愈合。

细胞外囊泡（EVs）在伤口愈合中的应用已得到充分证实。然而，在伤口部位直接皮下注射游离的 EVs 可能会导致生物活性成分迅速消散，降低疗效。功能化水凝胶可提供有效的保护，并确保 EVs 在伤口愈合过程中的持续释放和生物活性，因此是输送 EVs 的理想候选材料。在本综述中，我们将介绍 EVs 加速伤口愈合的机制，然后详细阐述工程化 EVs 的构建策略。随后，我们讨论了水凝胶的合成策略和应用，水凝胶是持续释放 EVs 以促进复杂伤口愈合的递送系统。此外，面对复杂伤口，具有特定伤口微环境调节能力（如抗菌、消炎和免疫调节）的功能化水凝胶可用于装载工程化 EVs，为应对这些愈合挑战提供了潜在的方法。最后，我们探讨了潜在的未来发展轨迹和前景，为人工智能（AI）激发材料和基于三维生物打印多功能水凝胶的工程化 EVs 输送敷料在生物医学领域的应用提供了新的视角。

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来源期刊

Theranostics MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

25.40

自引率

1.60%

发文量

433

审稿时长

1 months

期刊介绍： Theranostics serves as a pivotal platform for the exchange of clinical and scientific insights within the diagnostic and therapeutic molecular and nanomedicine community, along with allied professions engaged in integrating molecular imaging and therapy. As a multidisciplinary journal, Theranostics showcases innovative research articles spanning fields such as in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensor technology, nanobiosensors, bioelectronics, system biology, translational medicine, point-of-care applications, and personalized medicine. Encouraging a broad spectrum of biomedical research with potential theranostic applications, the journal rigorously peer-reviews primary research, alongside publishing reviews, news, and commentary that aim to bridge the gap between the laboratory, clinic, and biotechnology industries.